Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice

Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice

Background: The development of a protective vaccine is critical for conclusively ending the human immunodeficiency virus (HIV) epidemic. Methods: We constructed nucleotide-modified mRNA vaccines expressing HIV-1 Env and Gag proteins. Env–gag virus-like particles (VLPs) were generated through co-tran...

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Bibliographic Details
Main Authors: Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
HIV-1 vaccine
mRNA vaccine
VLP vaccine
Online Access:https://www.mdpi.com/2076-393X/13/1/84
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