A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis
There is significant interest in developing vaccines to control bovine tuberculosis, especially in wildlife species where this disease continues to persist in reservoir species such as the European Badger (Meles meles). However, gaining access to populations of badgers (protected under UK law) is pr...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2011/981410 |
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| author | Lyanne McCallan David Corbett Peter L. Andersen Claus Aagaard David McMurray Claire Barry Suzan Thompson Samuel Strain Jim McNair |
| author_facet | Lyanne McCallan David Corbett Peter L. Andersen Claus Aagaard David McMurray Claire Barry Suzan Thompson Samuel Strain Jim McNair |
| author_sort | Lyanne McCallan |
| collection | DOAJ |
| description | There is significant interest in developing vaccines to control bovine tuberculosis, especially in wildlife species where this disease continues to persist in reservoir species such as the European Badger (Meles meles). However, gaining access to populations of badgers (protected under UK law) is problematic and not always possible. In this study, a new infection model has been developed in ferrets (Mustela furo), a species which is closely related to the badger. Groups of ferrets were infected using a Madison infection chamber and were examined postmortem for the presence of tuberculous lesions and to provide tissue samples for confirmation of Mycobacterium bovis by culture. An infectious dose was defined, that establishes infection within the lungs and associated lymph nodes with subsequent spread to the mesentery lymph nodes. This model, which emphasises respiratory tract infection, will be used to evaluate vaccines for the control of bovine tuberculosis in wildlife species. |
| format | Article |
| id | doaj-art-dd7775ec507a4cc6b72adc41bede6e89 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-dd7775ec507a4cc6b72adc41bede6e892025-02-03T01:12:20ZengWileyVeterinary Medicine International2042-00482011-01-01201110.4061/2011/981410981410A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovisLyanne McCallan0David Corbett1Peter L. Andersen2Claus Aagaard3David McMurray4Claire Barry5Suzan Thompson6Samuel Strain7Jim McNair8Veterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UKVeterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UKDepartment of Infectious Immunology, Statens Serum Institut, 5 Artillerivej, 2300 Copenhagen S, DenmarkDepartment of Infectious Immunology, Statens Serum Institut, 5 Artillerivej, 2300 Copenhagen S, DenmarkDepartment of Microbial and Molecular Pathogenesis, Texas A&M University System Health Science Center, College Station, TX 77840-7896, USAVeterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UKVeterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UKVeterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UKVeterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UKThere is significant interest in developing vaccines to control bovine tuberculosis, especially in wildlife species where this disease continues to persist in reservoir species such as the European Badger (Meles meles). However, gaining access to populations of badgers (protected under UK law) is problematic and not always possible. In this study, a new infection model has been developed in ferrets (Mustela furo), a species which is closely related to the badger. Groups of ferrets were infected using a Madison infection chamber and were examined postmortem for the presence of tuberculous lesions and to provide tissue samples for confirmation of Mycobacterium bovis by culture. An infectious dose was defined, that establishes infection within the lungs and associated lymph nodes with subsequent spread to the mesentery lymph nodes. This model, which emphasises respiratory tract infection, will be used to evaluate vaccines for the control of bovine tuberculosis in wildlife species.http://dx.doi.org/10.4061/2011/981410 |
| spellingShingle | Lyanne McCallan David Corbett Peter L. Andersen Claus Aagaard David McMurray Claire Barry Suzan Thompson Samuel Strain Jim McNair A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis Veterinary Medicine International |
| title | A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis |
| title_full | A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis |
| title_fullStr | A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis |
| title_full_unstemmed | A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis |
| title_short | A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis |
| title_sort | new experimental infection model in ferrets based on aerosolised mycobacterium bovis |
| url | http://dx.doi.org/10.4061/2011/981410 |
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