Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats
Objective: To investigate the protective effect and mechanism of Lyophyllum ulmarium fibrinolytic enzyme （LUFE） on rats with hyperlipidemia. Methods: Hyperlipidemia models were established by feeding with a high-fat diet, and the model rats were gavaged with different doses of LUFE. HE stain was use...
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The Editorial Office of Food and Machinery
2023-06-01
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| Series: | Shipin yu jixie |
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| Online Access: | http://www.ifoodmm.com/spyjxen/article/abstract/20230426 |
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| author | LI Yu SU Xin ZHANG Jun-hui ZHANG Rui-meng SHEN Ming-hua |
| author_facet | LI Yu SU Xin ZHANG Jun-hui ZHANG Rui-meng SHEN Ming-hua |
| author_sort | LI Yu |
| collection | DOAJ |
| description | Objective: To investigate the protective effect and mechanism of Lyophyllum ulmarium fibrinolytic enzyme （LUFE） on rats with hyperlipidemia. Methods: Hyperlipidemia models were established by feeding with a high-fat diet, and the model rats were gavaged with different doses of LUFE. HE stain was used to analyze the morphological changes of liver.The biochemical indexes of rat plasma were detected by colorimetric method.WB analyses the expression level of related proteins. Results: LUFE could alleviate the liver tissue injury of hyperlipidemia rats and reduce the plasma lipid level and IL-6, TNF-α，MCP-1，ALT，AST. LUFE can down regulate TLR4，MyD88，phosphorylated PI3K，phosphorylated Akt and phosphorylated NF-кB protein level. Conclusion: LUFE protects against hyperlipidemia-induced liver injury in rats by regulating PI3K/Akt/NF-кB and TLR4/MyD88/NF-кB signaling pathways. |
| format | Article |
| id | doaj-art-dd6a28d7411e41b9b51c781fd4cda46a |
| institution | OA Journals |
| issn | 1003-5788 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | The Editorial Office of Food and Machinery |
| record_format | Article |
| series | Shipin yu jixie |
| spelling | doaj-art-dd6a28d7411e41b9b51c781fd4cda46a2025-08-20T02:21:49ZengThe Editorial Office of Food and MachineryShipin yu jixie1003-57882023-06-0139415616210.13652/j.spjx.1003.5788.2022.80658Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia ratsLI Yu0SU Xin1ZHANG Jun-hui2ZHANG Rui-meng3SHEN Ming-hua4 Medical College of Yanbian University, Yanji, Jilin 133000 , China Medical College of Yanbian University, Yanji, Jilin 133000 , China Medical College of Yanbian University, Yanji, Jilin 133000 , China Medical College of Yanbian University, Yanji, Jilin 133000 , China Medical College of Yanbian University, Yanji, Jilin 133000 , China Objective: To investigate the protective effect and mechanism of Lyophyllum ulmarium fibrinolytic enzyme （LUFE） on rats with hyperlipidemia. Methods: Hyperlipidemia models were established by feeding with a high-fat diet, and the model rats were gavaged with different doses of LUFE. HE stain was used to analyze the morphological changes of liver.The biochemical indexes of rat plasma were detected by colorimetric method.WB analyses the expression level of related proteins. Results: LUFE could alleviate the liver tissue injury of hyperlipidemia rats and reduce the plasma lipid level and IL-6, TNF-α，MCP-1，ALT，AST. LUFE can down regulate TLR4，MyD88，phosphorylated PI3K，phosphorylated Akt and phosphorylated NF-кB protein level. Conclusion: LUFE protects against hyperlipidemia-induced liver injury in rats by regulating PI3K/Akt/NF-кB and TLR4/MyD88/NF-кB signaling pathways.http://www.ifoodmm.com/spyjxen/article/abstract/20230426 lyophyllum ulmarium fibrinolytic enzyme hyperlipidemia liver injury inflammation |
| spellingShingle | LI Yu SU Xin ZHANG Jun-hui ZHANG Rui-meng SHEN Ming-hua Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats Shipin yu jixie lyophyllum ulmarium fibrinolytic enzyme hyperlipidemia liver injury inflammation |
| title | Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats |
| title_full | Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats |
| title_fullStr | Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats |
| title_full_unstemmed | Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats |
| title_short | Protective effect of Lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats |
| title_sort | protective effect of lyophyllum ulmarium fibrolytic enzyme on liver injury induced in hyperlipidemia rats |
| topic | lyophyllum ulmarium fibrinolytic enzyme hyperlipidemia liver injury inflammation |
| url | http://www.ifoodmm.com/spyjxen/article/abstract/20230426 |
| work_keys_str_mv | AT liyu protectiveeffectoflyophyllumulmariumfibrolyticenzymeonliverinjuryinducedinhyperlipidemiarats AT suxin protectiveeffectoflyophyllumulmariumfibrolyticenzymeonliverinjuryinducedinhyperlipidemiarats AT zhangjunhui protectiveeffectoflyophyllumulmariumfibrolyticenzymeonliverinjuryinducedinhyperlipidemiarats AT zhangruimeng protectiveeffectoflyophyllumulmariumfibrolyticenzymeonliverinjuryinducedinhyperlipidemiarats AT shenminghua protectiveeffectoflyophyllumulmariumfibrolyticenzymeonliverinjuryinducedinhyperlipidemiarats |