DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease
Hippocampal damage, by DTI or MR volumetry, and PET hypoperfusion of precuneus/posterior cingulate cortex (PC/PCC) were proposed as biomarkers of conversion from preclinical (MCI) to clinical stage of Alzheimer's disease (AD). This study evaluated structural damage, by DTI and MR volumetry, of...
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/517876 |
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| author | F. Palesi P. Vitali P. Chiarati G. Castellazzi E. Caverzasi A. Pichiecchio E. Colli-Tibaldi F. D'Amore I. D'Errico E. Sinforiani S. Bastianello |
| author_facet | F. Palesi P. Vitali P. Chiarati G. Castellazzi E. Caverzasi A. Pichiecchio E. Colli-Tibaldi F. D'Amore I. D'Errico E. Sinforiani S. Bastianello |
| author_sort | F. Palesi |
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| description | Hippocampal damage, by DTI or MR volumetry, and PET hypoperfusion of precuneus/posterior cingulate cortex (PC/PCC) were proposed as biomarkers of conversion from preclinical (MCI) to clinical stage of Alzheimer's disease (AD). This study evaluated structural damage, by DTI and MR volumetry, of hippocampi and tracts connecting hippocampus to PC/PCC (hipp-PC/PCC) in 10 AD, 10 MCI, and 18 healthy controls (CTRL). Normalized volumes, mean diffusivity (MD), and fractional anisotropy (FA) were obtained for grey matter (GM), white matter (WM), hippocampi, PC/PCC, and hipp-PC/PCC tracts. In hippocampi and hipp-PC/PCC tracts, decreased volumes and increased MD were found in AD versus CTRL (𝑃<.001). The same results with lower significance (𝑃<.05) were found in MCI versus CTRL. Verbal memory correlated (𝑃<.05) in AD with left hippocampal and hipp-PC/PCC tract MD, and in MCI with FA of total WM. Both DTI and MR volumetry of hippocampi and hipp-PC/PCC tracts detect early signs of AD in MCI patients. |
| format | Article |
| id | doaj-art-dd5e86129e3043f2ad070f948cb53096 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-dd5e86129e3043f2ad070f948cb530962025-02-03T06:14:13ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/517876517876DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's DiseaseF. Palesi0P. Vitali1P. Chiarati2G. Castellazzi3E. Caverzasi4A. Pichiecchio5E. Colli-Tibaldi6F. D'Amore7I. D'Errico8E. Sinforiani9S. Bastianello10Neuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeurology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyNeuroradiology Unit, IRCCS Foundation National Neurological Institute C. Mondino, 27100 Pavia, ItalyHippocampal damage, by DTI or MR volumetry, and PET hypoperfusion of precuneus/posterior cingulate cortex (PC/PCC) were proposed as biomarkers of conversion from preclinical (MCI) to clinical stage of Alzheimer's disease (AD). This study evaluated structural damage, by DTI and MR volumetry, of hippocampi and tracts connecting hippocampus to PC/PCC (hipp-PC/PCC) in 10 AD, 10 MCI, and 18 healthy controls (CTRL). Normalized volumes, mean diffusivity (MD), and fractional anisotropy (FA) were obtained for grey matter (GM), white matter (WM), hippocampi, PC/PCC, and hipp-PC/PCC tracts. In hippocampi and hipp-PC/PCC tracts, decreased volumes and increased MD were found in AD versus CTRL (𝑃<.001). The same results with lower significance (𝑃<.05) were found in MCI versus CTRL. Verbal memory correlated (𝑃<.05) in AD with left hippocampal and hipp-PC/PCC tract MD, and in MCI with FA of total WM. Both DTI and MR volumetry of hippocampi and hipp-PC/PCC tracts detect early signs of AD in MCI patients.http://dx.doi.org/10.1155/2012/517876 |
| spellingShingle | F. Palesi P. Vitali P. Chiarati G. Castellazzi E. Caverzasi A. Pichiecchio E. Colli-Tibaldi F. D'Amore I. D'Errico E. Sinforiani S. Bastianello DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease Neurology Research International |
| title | DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease |
| title_full | DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease |
| title_fullStr | DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease |
| title_full_unstemmed | DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease |
| title_short | DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease |
| title_sort | dti and mr volumetry of hippocampus pc pcc circuit in search of early micro and macrostructural signs of alzheimers s disease |
| url | http://dx.doi.org/10.1155/2012/517876 |
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