Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma
The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R a...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000433 |
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| _version_ | 1832554669096828928 |
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| author | G. Di Lorenzo P. Mansueto M. Melluso G. Morici F. Norrito D. Cigna G. Candore C. Caruso |
| author_facet | G. Di Lorenzo P. Mansueto M. Melluso G. Morici F. Norrito D. Cigna G. Candore C. Caruso |
| author_sort | G. Di Lorenzo |
| collection | DOAJ |
| description | The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. In contrast, lower levels of soluble CD8 values were found in patients with asthma compared to the control group. Significant correlations were found for both sIL-2R and sCD4 and these two molecules, with lung function measured as bronchial responsiveness to inhaled methacholine. These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis. |
| format | Article |
| id | doaj-art-dd4f049bdcf046c8aeeb526cba53a4b6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dd4f049bdcf046c8aeeb526cba53a4b62025-02-03T05:51:01ZengWileyMediators of Inflammation0962-93511466-18611995-01-014427027210.1155/S0962935195000433Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthmaG. Di Lorenzo0P. Mansueto1M. Melluso2G. Morici3F. Norrito4D. Cigna5G. Candore6C. Caruso7Istituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, 141, Palermo 90127, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, 141, Palermo 90127, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, 141, Palermo 90127, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, 141, Palermo 90127, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, 141, Palermo 90127, ItalyIstituto di Patologia Generale, Università di Palermo, Corse Tukory 21 1, Palermo 90134, ItalyIstituto di Patologia Generale, Università di Palermo, Corse Tukory 21 1, Palermo 90134, ItalyIstituto di Patologia Generale, Università di Palermo, Corse Tukory 21 1, Palermo 90134, ItalyThe aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. In contrast, lower levels of soluble CD8 values were found in patients with asthma compared to the control group. Significant correlations were found for both sIL-2R and sCD4 and these two molecules, with lung function measured as bronchial responsiveness to inhaled methacholine. These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis.http://dx.doi.org/10.1155/S0962935195000433 |
| spellingShingle | G. Di Lorenzo P. Mansueto M. Melluso G. Morici F. Norrito D. Cigna G. Candore C. Caruso Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma Mediators of Inflammation |
| title | Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma |
| title_full | Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma |
| title_fullStr | Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma |
| title_full_unstemmed | Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma |
| title_short | Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma |
| title_sort | serum levels of soluble il 2r cd4 and cd8 in bronchial asthma |
| url | http://dx.doi.org/10.1155/S0962935195000433 |
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