Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies
Particulate matter (PM), particularly fine (PM<sub>2.5</sub>) and ultrafine (PM<sub>0.1</sub>) particles, originates from both natural and anthropogenic sources, such as biomass burning and vehicle emissions. These particles contain harmful compounds that pose significant hea...
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MDPI AG
2024-12-01
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| Series: | Antioxidants |
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| author | Aekkhaluck Intharuksa Warunya Arunotayanun Mingkwan Na Takuathung Yaowatat Boongla Siripat Chaichit Suthiwat Khamnuan Anchalee Prasansuklab |
| author_facet | Aekkhaluck Intharuksa Warunya Arunotayanun Mingkwan Na Takuathung Yaowatat Boongla Siripat Chaichit Suthiwat Khamnuan Anchalee Prasansuklab |
| author_sort | Aekkhaluck Intharuksa |
| collection | DOAJ |
| description | Particulate matter (PM), particularly fine (PM<sub>2.5</sub>) and ultrafine (PM<sub>0.1</sub>) particles, originates from both natural and anthropogenic sources, such as biomass burning and vehicle emissions. These particles contain harmful compounds that pose significant health risks. Upon inhalation, ingestion, or dermal contact, PM can penetrate biological systems, inducing oxidative stress, inflammation, and DNA damage, which contribute to a range of health complications. This review comprehensively examines the protective potential of natural products against PM-induced health issues across various physiological systems, including the respiratory, cardiovascular, skin, neurological, gastrointestinal, and ocular systems. It provides valuable insights into the health risks associated with PM exposure and highlights the therapeutic promise of herbal medicines by focusing on the natural products that have demonstrated protective properties in both in vitro and in vivo PM<sub>2.5</sub>-induced models. Numerous herbal medicines and phytochemicals have shown efficacy in mitigating PM-induced cellular damage through their ability to counteract oxidative stress, suppress pro-inflammatory responses, and enhance cellular defense mechanisms. These combined actions collectively protect tissues from PM-related damage and dysfunction. This review establishes a foundation for future research and the development of effective interventions to combat PM-related health issues. However, further studies, including in vivo and clinical trials, are essential to evaluate the safety, optimal dosages, and long-term effectiveness of herbal treatments for patients under chronic PM exposure. |
| format | Article |
| id | doaj-art-dd4b9c3b4b38460b9497e37685f0b2d2 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-dd4b9c3b4b38460b9497e37685f0b2d22025-01-24T13:19:11ZengMDPI AGAntioxidants2076-39212024-12-011412310.3390/antiox14010023Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent StudiesAekkhaluck Intharuksa0Warunya Arunotayanun1Mingkwan Na Takuathung2Yaowatat Boongla3Siripat Chaichit4Suthiwat Khamnuan5Anchalee Prasansuklab6Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandKanchanabhishek Institute of Medical and Public Health Technology, Faculty of Public Health and Allied Health Science, Praboromarajchanok Institute, Nonthaburi 11150, ThailandDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Sustainable Development Technology, Faculty of Science and Technology, Thammasat University, Pathum Thani 12120, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandFaculty of Pharmacy, Western University, Pathum Thani 12150, ThailandCollege of Public Health Sciences, Chulalongkorn University, Bangkok 10330, ThailandParticulate matter (PM), particularly fine (PM<sub>2.5</sub>) and ultrafine (PM<sub>0.1</sub>) particles, originates from both natural and anthropogenic sources, such as biomass burning and vehicle emissions. These particles contain harmful compounds that pose significant health risks. Upon inhalation, ingestion, or dermal contact, PM can penetrate biological systems, inducing oxidative stress, inflammation, and DNA damage, which contribute to a range of health complications. This review comprehensively examines the protective potential of natural products against PM-induced health issues across various physiological systems, including the respiratory, cardiovascular, skin, neurological, gastrointestinal, and ocular systems. It provides valuable insights into the health risks associated with PM exposure and highlights the therapeutic promise of herbal medicines by focusing on the natural products that have demonstrated protective properties in both in vitro and in vivo PM<sub>2.5</sub>-induced models. Numerous herbal medicines and phytochemicals have shown efficacy in mitigating PM-induced cellular damage through their ability to counteract oxidative stress, suppress pro-inflammatory responses, and enhance cellular defense mechanisms. These combined actions collectively protect tissues from PM-related damage and dysfunction. This review establishes a foundation for future research and the development of effective interventions to combat PM-related health issues. However, further studies, including in vivo and clinical trials, are essential to evaluate the safety, optimal dosages, and long-term effectiveness of herbal treatments for patients under chronic PM exposure.https://www.mdpi.com/2076-3921/14/1/23air pollutionenvironmental hazardsherbal medicineinflammationoxidative stressphytochemicals |
| spellingShingle | Aekkhaluck Intharuksa Warunya Arunotayanun Mingkwan Na Takuathung Yaowatat Boongla Siripat Chaichit Suthiwat Khamnuan Anchalee Prasansuklab Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies Antioxidants air pollution environmental hazards herbal medicine inflammation oxidative stress phytochemicals |
| title | Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies |
| title_full | Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies |
| title_fullStr | Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies |
| title_full_unstemmed | Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies |
| title_short | Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies |
| title_sort | therapeutic potential of herbal medicines in combating particulate matter pm induced health effects insights from recent studies |
| topic | air pollution environmental hazards herbal medicine inflammation oxidative stress phytochemicals |
| url | https://www.mdpi.com/2076-3921/14/1/23 |
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