G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells

G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells

Abstract Background Epigenetic evolution is a common mechanism used by cancer cells to evade the therapeutic effects of drug treatment. In ovarian cancers, epigenetically driven resistance is thought to be responsible for many late-stage patient deaths. DNA secondary structures called G-quadruplexes...

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Bibliographic Details
Main Authors: Jenna Robinson, Gem Flint, Ian Garner, Silvia Galli, Thomas E. Maher, Marina K. Kuimova, Ramon Vilar, Iain A. McNeish, Robert Brown, Hector Keun, Marco Di Antonio
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
G-quadruplexes
Resistance
Ovarian cancer
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Online Access:https://doi.org/10.1186/s13059-025-03654-y
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