Association between Circulating Ectodysplasin A and Diabetic Kidney Disease
Background. Ectodysplasin A (EDA), a member of the TNF family, plays important roles in ectodermal development, while recent studies expanded its regulatory effects on insulin resistance and lipid metabolism. This study was the first time to investigate the correlation between circulating EDA and al...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2023/5087761 |
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| _version_ | 1832546771225542656 |
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| author | Xia Deng Chang Guo Huijuan Qin Li Zhao Yanyan Li Zhicong Zhao Haoxiang Li Ling Yang Dong Wang Guoyue Yuan |
| author_facet | Xia Deng Chang Guo Huijuan Qin Li Zhao Yanyan Li Zhicong Zhao Haoxiang Li Ling Yang Dong Wang Guoyue Yuan |
| author_sort | Xia Deng |
| collection | DOAJ |
| description | Background. Ectodysplasin A (EDA), a member of the TNF family, plays important roles in ectodermal development, while recent studies expanded its regulatory effects on insulin resistance and lipid metabolism. This study was the first time to investigate the correlation between circulating EDA and albuminuria in patients with T2DM. Methods. A total of 189 T2DM and 59 healthy subjects were enrolled in the study. We analyzed the concentrations of EDA by ELISA. Plasma glucose, insulin, HbA1c, lipids, creatinine, BUN, and UACR were also measured. Insulin resistance and pancreatic cell function were assessed by HOMA. Results. Circulating EDA concentration was significantly increased in T2DM patients and increased with the degree of albuminuria. EDA was positively correlated with age, FIns, HOMA-IR, HOMA-β, Scr, and UACR, and negatively correlated with eGFR. Linear stepwise regression showed that FIns, HOMA-β, and UACR were independent influencing factors of EDA. Logistic regression analysis showed that EDA was independently associated with the occurrence of albuminuria in T2DM. ROC curve showed that EDA had an area under the receiver operating curve of 0.701 [95%CI=0.625−0.777, P<0.001]. Conclusion. EDA is positively correlated with the degree of albuminuria in patients with T2DM and may be involved in the occurrence and progression of diabetic kidney disease (DKD). |
| format | Article |
| id | doaj-art-dd21169fe8a14575875ee4d992c6d895 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-dd21169fe8a14575875ee4d992c6d8952025-02-03T06:47:16ZengWileyJournal of Diabetes Research2314-67532023-01-01202310.1155/2023/5087761Association between Circulating Ectodysplasin A and Diabetic Kidney DiseaseXia Deng0Chang Guo1Huijuan Qin2Li Zhao3Yanyan Li4Zhicong Zhao5Haoxiang Li6Ling Yang7Dong Wang8Guoyue Yuan9Department of EndocrinologyDepartment of NephrologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyBackground. Ectodysplasin A (EDA), a member of the TNF family, plays important roles in ectodermal development, while recent studies expanded its regulatory effects on insulin resistance and lipid metabolism. This study was the first time to investigate the correlation between circulating EDA and albuminuria in patients with T2DM. Methods. A total of 189 T2DM and 59 healthy subjects were enrolled in the study. We analyzed the concentrations of EDA by ELISA. Plasma glucose, insulin, HbA1c, lipids, creatinine, BUN, and UACR were also measured. Insulin resistance and pancreatic cell function were assessed by HOMA. Results. Circulating EDA concentration was significantly increased in T2DM patients and increased with the degree of albuminuria. EDA was positively correlated with age, FIns, HOMA-IR, HOMA-β, Scr, and UACR, and negatively correlated with eGFR. Linear stepwise regression showed that FIns, HOMA-β, and UACR were independent influencing factors of EDA. Logistic regression analysis showed that EDA was independently associated with the occurrence of albuminuria in T2DM. ROC curve showed that EDA had an area under the receiver operating curve of 0.701 [95%CI=0.625−0.777, P<0.001]. Conclusion. EDA is positively correlated with the degree of albuminuria in patients with T2DM and may be involved in the occurrence and progression of diabetic kidney disease (DKD).http://dx.doi.org/10.1155/2023/5087761 |
| spellingShingle | Xia Deng Chang Guo Huijuan Qin Li Zhao Yanyan Li Zhicong Zhao Haoxiang Li Ling Yang Dong Wang Guoyue Yuan Association between Circulating Ectodysplasin A and Diabetic Kidney Disease Journal of Diabetes Research |
| title | Association between Circulating Ectodysplasin A and Diabetic Kidney Disease |
| title_full | Association between Circulating Ectodysplasin A and Diabetic Kidney Disease |
| title_fullStr | Association between Circulating Ectodysplasin A and Diabetic Kidney Disease |
| title_full_unstemmed | Association between Circulating Ectodysplasin A and Diabetic Kidney Disease |
| title_short | Association between Circulating Ectodysplasin A and Diabetic Kidney Disease |
| title_sort | association between circulating ectodysplasin a and diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2023/5087761 |
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