The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions
DNA polymerase _ (pol _) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2003.05 |
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| author | Marco Muzi-Falconi Michele Giannattasio Marco Foiani Paolo Plevani |
| author_facet | Marco Muzi-Falconi Michele Giannattasio Marco Foiani Paolo Plevani |
| author_sort | Marco Muzi-Falconi |
| collection | DOAJ |
| description | DNA polymerase _ (pol _) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly. |
| format | Article |
| id | doaj-art-dd1fe086cc6744468d73d12344eac96f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-dd1fe086cc6744468d73d12344eac96f2025-02-03T01:25:22ZengWileyThe Scientific World Journal1537-744X2003-01-013213310.1100/tsw.2003.05The DNA Polymerase _-Primase Complex: Multiple Functions and InteractionsMarco Muzi-Falconi0Michele Giannattasio1Marco Foiani2Paolo Plevani3Dipartimento di Genetica e di Biologia dei Microrganismi, Universit? degli Studi di Milano, Via Celoria 26, 20133 Milano, ItalyDipartimento di Genetica e di Biologia dei Microrganismi, Universit? degli Studi di Milano, Via Celoria 26, 20133 Milano, ItalyDipartimento di Genetica e di Biologia dei Microrganismi, Universit? degli Studi di Milano, Via Celoria 26, 20133 Milano, ItalyDipartimento di Genetica e di Biologia dei Microrganismi, Universit? degli Studi di Milano, Via Celoria 26, 20133 Milano, ItalyDNA polymerase _ (pol _) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.http://dx.doi.org/10.1100/tsw.2003.05 |
| spellingShingle | Marco Muzi-Falconi Michele Giannattasio Marco Foiani Paolo Plevani The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions The Scientific World Journal |
| title | The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions |
| title_full | The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions |
| title_fullStr | The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions |
| title_full_unstemmed | The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions |
| title_short | The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions |
| title_sort | dna polymerase primase complex multiple functions and interactions |
| url | http://dx.doi.org/10.1100/tsw.2003.05 |
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