The Role of Inflammation in the Pathogenesis of Osteoarthritis
A joint is the point of connection between two bones in our body. Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review. Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly. Several studies showed tha...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/8293921 |
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| _version_ | 1832547116269961216 |
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| author | Yoke Yue Chow Kok-Yong Chin |
| author_facet | Yoke Yue Chow Kok-Yong Chin |
| author_sort | Yoke Yue Chow |
| collection | DOAJ |
| description | A joint is the point of connection between two bones in our body. Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review. Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly. Several studies showed that inflammation triggered by factors like biomechanical stress is involved in the development of osteoarthritis. This stimulates the release of early-stage inflammatory cytokines like interleukin-1 beta (IL-1β), which in turn induces the activation of signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and mitogen-activated protein kinase (MAPK). These events, in turn, generate more inflammatory molecules. Subsequently, collagenase like matrix metalloproteinases-13 (MMP-13) will degrade the extracellular matrix. As a result, anatomical and physiological functions of the joint are altered. This review is aimed at summarizing the previous studies highlighting the involvement of inflammation in the pathogenesis of osteoarthritis. |
| format | Article |
| id | doaj-art-dd0fb837755e4a4380ee8cf322937afc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dd0fb837755e4a4380ee8cf322937afc2025-02-03T06:46:08ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/82939218293921The Role of Inflammation in the Pathogenesis of OsteoarthritisYoke Yue Chow0Kok-Yong Chin1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, MalaysiaA joint is the point of connection between two bones in our body. Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review. Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly. Several studies showed that inflammation triggered by factors like biomechanical stress is involved in the development of osteoarthritis. This stimulates the release of early-stage inflammatory cytokines like interleukin-1 beta (IL-1β), which in turn induces the activation of signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and mitogen-activated protein kinase (MAPK). These events, in turn, generate more inflammatory molecules. Subsequently, collagenase like matrix metalloproteinases-13 (MMP-13) will degrade the extracellular matrix. As a result, anatomical and physiological functions of the joint are altered. This review is aimed at summarizing the previous studies highlighting the involvement of inflammation in the pathogenesis of osteoarthritis.http://dx.doi.org/10.1155/2020/8293921 |
| spellingShingle | Yoke Yue Chow Kok-Yong Chin The Role of Inflammation in the Pathogenesis of Osteoarthritis Mediators of Inflammation |
| title | The Role of Inflammation in the Pathogenesis of Osteoarthritis |
| title_full | The Role of Inflammation in the Pathogenesis of Osteoarthritis |
| title_fullStr | The Role of Inflammation in the Pathogenesis of Osteoarthritis |
| title_full_unstemmed | The Role of Inflammation in the Pathogenesis of Osteoarthritis |
| title_short | The Role of Inflammation in the Pathogenesis of Osteoarthritis |
| title_sort | role of inflammation in the pathogenesis of osteoarthritis |
| url | http://dx.doi.org/10.1155/2020/8293921 |
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