Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease

Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease

Abstract Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn...

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Bibliographic Details
Main Authors: Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter, Björn H. Falkenburger
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Acta Neuropathologica Communications
Subjects:
Seed amplification assay
Parkinson’s disease
Strains
RT-QuIC
Alpha-synuclein
Online Access:https://doi.org/10.1186/s40478-024-01923-8
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