Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism
The diagnosis of central hypothyroidism is often suspected in patients with hypothalamic/pituitary pathology, in the setting of low, normal, or even slightly elevated serum TSH and low free thyroxine (FT4). We present four cases of central hypothyroidism (three had known pituitary pathology) in whom...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/965191 |
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| author | Kevin M. Pantalone Betul Hatipoglu Manjula K. Gupta Laurence Kennedy Amir H. Hamrahian |
| author_facet | Kevin M. Pantalone Betul Hatipoglu Manjula K. Gupta Laurence Kennedy Amir H. Hamrahian |
| author_sort | Kevin M. Pantalone |
| collection | DOAJ |
| description | The diagnosis of central hypothyroidism is often suspected in patients with hypothalamic/pituitary pathology, in the setting of low, normal, or even slightly elevated serum TSH and low free thyroxine (FT4). We present four cases of central hypothyroidism (three had known pituitary pathology) in whom central hypothyroidism was diagnosed after the serum free thyroxine index (FTI) was found to be low. All had normal range serum TSH and free thyroxine levels. This report illustrates that the assessment of the serum FTI may be helpful in making the diagnosis of central hypothyroidism in the appropriate clinical setting and when free T4 is in the low-normal range, particularly in patients with multiple anterior pituitary hormone deficiencies and/or with symptoms suggestive of hypothyroidism. |
| format | Article |
| id | doaj-art-dcfe46d067b64a1ca9de0fb795c1916a |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-dcfe46d067b64a1ca9de0fb795c1916a2025-02-03T06:44:42ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/965191965191Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central HypothyroidismKevin M. Pantalone0Betul Hatipoglu1Manjula K. Gupta2Laurence Kennedy3Amir H. Hamrahian4Endocrinology and Metabolism Institute, Cleveland Clinic, Desk F-20, 9500 Euclid Avenue, Cleveland, OH 44195, USAEndocrinology and Metabolism Institute, Cleveland Clinic, Desk F-20, 9500 Euclid Avenue, Cleveland, OH 44195, USAPathology and Laboratory Medicine Institute, Cleveland Clinic, Desk LL3-140, 9500 Euclid Avenue, Cleveland, OH 44195, USAEndocrinology and Metabolism Institute, Cleveland Clinic, Desk F-20, 9500 Euclid Avenue, Cleveland, OH 44195, USAEndocrinology and Metabolism Institute, Cleveland Clinic, Desk F-20, 9500 Euclid Avenue, Cleveland, OH 44195, USAThe diagnosis of central hypothyroidism is often suspected in patients with hypothalamic/pituitary pathology, in the setting of low, normal, or even slightly elevated serum TSH and low free thyroxine (FT4). We present four cases of central hypothyroidism (three had known pituitary pathology) in whom central hypothyroidism was diagnosed after the serum free thyroxine index (FTI) was found to be low. All had normal range serum TSH and free thyroxine levels. This report illustrates that the assessment of the serum FTI may be helpful in making the diagnosis of central hypothyroidism in the appropriate clinical setting and when free T4 is in the low-normal range, particularly in patients with multiple anterior pituitary hormone deficiencies and/or with symptoms suggestive of hypothyroidism.http://dx.doi.org/10.1155/2015/965191 |
| spellingShingle | Kevin M. Pantalone Betul Hatipoglu Manjula K. Gupta Laurence Kennedy Amir H. Hamrahian Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism Case Reports in Endocrinology |
| title | Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism |
| title_full | Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism |
| title_fullStr | Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism |
| title_full_unstemmed | Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism |
| title_short | Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism |
| title_sort | measurement of serum free thyroxine index may provide additional case detection compared to free thyroxine in the diagnosis of central hypothyroidism |
| url | http://dx.doi.org/10.1155/2015/965191 |
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