Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer
Gastric cancer is the sixth highest incidence rate in the world. Although treatment has made progress, the prospect of gastric cancer patients is bleak. Difficulties and future prospects of immunotherapy in cancer treatment. Adaptive cell therapy, cancer vaccines, gene therapy, and monoclonal antibo...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2023/6905216 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559518936989696 |
|---|---|
| author | Xiao Li Yanghao Tai Shuying Liu Yating Gao Kaining Zhang Jierong Yin Huijuan Zhang Xia Wang Xiaofei Li Dongfeng Zhang |
| author_facet | Xiao Li Yanghao Tai Shuying Liu Yating Gao Kaining Zhang Jierong Yin Huijuan Zhang Xia Wang Xiaofei Li Dongfeng Zhang |
| author_sort | Xiao Li |
| collection | DOAJ |
| description | Gastric cancer is the sixth highest incidence rate in the world. Although treatment has made progress, the prospect of gastric cancer patients is bleak. Difficulties and future prospects of immunotherapy in cancer treatment. Adaptive cell therapy, cancer vaccines, gene therapy, and monoclonal antibody therapy have all been used in gastric cancer with some initial success. PTTGs (pituitary tumor-transforming genes) have been proven to be closely related to the prognosis of many malignant tumors. However, the prognosis and immune cell infiltration of gastric adenocarcinoma (STAD) remain unclear. We retrieved multiple databases to understand the possible activity of PTTGs and their expression in gastric cancer, as well as their relationship with clinical data, overall survival rate, first progression, and survival rate after progression. PTTGs are overexpressed in STAD tumor tissues. Many clinical variables are closely related to PTTGs. In addition, PTTG was associated with overall survival independent of disease. In addition, the expression of PTTG1/2 was positively correlated with the molecular status of the immune checkpoint and negatively correlated with the infiltration of various immune cells. Data research shows that PTTG and STAD are closely related. This paved the way for future research, revealed the complex pathophysiology of gastric cancer, and introduced an effective new treatment. |
| format | Article |
| id | doaj-art-dcee4b1dd0cf43fa8941ec7446903f42 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-dcee4b1dd0cf43fa8941ec7446903f422025-02-03T01:29:52ZengWileyStem Cells International1687-96782023-01-01202310.1155/2023/6905216Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric CancerXiao Li0Yanghao Tai1Shuying Liu2Yating Gao3Kaining Zhang4Jierong Yin5Huijuan Zhang6Xia Wang7Xiaofei Li8Dongfeng Zhang9Department of Thoracic OncologyShanxi Medical UniversityDepartment of Thoracic OncologyDepartment of Thoracic OncologyDepartment of Thoracic OncologyDepartment of Thoracic OncologyDepartment of Thoracic OncologyDepartment of Thoracic OncologyDepartment of Thoracic OncologyDepartment of Thoracic OncologyGastric cancer is the sixth highest incidence rate in the world. Although treatment has made progress, the prospect of gastric cancer patients is bleak. Difficulties and future prospects of immunotherapy in cancer treatment. Adaptive cell therapy, cancer vaccines, gene therapy, and monoclonal antibody therapy have all been used in gastric cancer with some initial success. PTTGs (pituitary tumor-transforming genes) have been proven to be closely related to the prognosis of many malignant tumors. However, the prognosis and immune cell infiltration of gastric adenocarcinoma (STAD) remain unclear. We retrieved multiple databases to understand the possible activity of PTTGs and their expression in gastric cancer, as well as their relationship with clinical data, overall survival rate, first progression, and survival rate after progression. PTTGs are overexpressed in STAD tumor tissues. Many clinical variables are closely related to PTTGs. In addition, PTTG was associated with overall survival independent of disease. In addition, the expression of PTTG1/2 was positively correlated with the molecular status of the immune checkpoint and negatively correlated with the infiltration of various immune cells. Data research shows that PTTG and STAD are closely related. This paved the way for future research, revealed the complex pathophysiology of gastric cancer, and introduced an effective new treatment.http://dx.doi.org/10.1155/2023/6905216 |
| spellingShingle | Xiao Li Yanghao Tai Shuying Liu Yating Gao Kaining Zhang Jierong Yin Huijuan Zhang Xia Wang Xiaofei Li Dongfeng Zhang Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer Stem Cells International |
| title | Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer |
| title_full | Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer |
| title_fullStr | Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer |
| title_full_unstemmed | Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer |
| title_short | Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer |
| title_sort | bioinformatic analysis of pttg family and prognosis and immune cell infiltration in gastric cancer |
| url | http://dx.doi.org/10.1155/2023/6905216 |
| work_keys_str_mv | AT xiaoli bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT yanghaotai bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT shuyingliu bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT yatinggao bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT kainingzhang bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT jierongyin bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT huijuanzhang bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT xiawang bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT xiaofeili bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer AT dongfengzhang bioinformaticanalysisofpttgfamilyandprognosisandimmunecellinfiltrationingastriccancer |