Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-ce...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/731486 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550382347223040 |
|---|---|
| author | Yan Wang Xiaodong Gu Jianbin Xiang Zongyou Chen |
| author_facet | Yan Wang Xiaodong Gu Jianbin Xiang Zongyou Chen |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance. |
| format | Article |
| id | doaj-art-dce865ac614b43e2b9b646533d78e38d |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-dce865ac614b43e2b9b646533d78e38d2025-02-03T06:06:59ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/731486731486Myeloid-Derived Suppressor Cells Participate in Preventing Graft RejectionYan Wang0Xiaodong Gu1Jianbin Xiang2Zongyou Chen3Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaMyeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.http://dx.doi.org/10.1155/2012/731486 |
| spellingShingle | Yan Wang Xiaodong Gu Jianbin Xiang Zongyou Chen Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection Clinical and Developmental Immunology |
| title | Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection |
| title_full | Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection |
| title_fullStr | Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection |
| title_full_unstemmed | Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection |
| title_short | Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection |
| title_sort | myeloid derived suppressor cells participate in preventing graft rejection |
| url | http://dx.doi.org/10.1155/2012/731486 |
| work_keys_str_mv | AT yanwang myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection AT xiaodonggu myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection AT jianbinxiang myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection AT zongyouchen myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection |