Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report
Toxic Epidermal Necrolysis (TEN) is a severe skin-mucosal reaction induced by medications, commonly characterized by blister formation and widespread epidermal detachment. Typical causative agents include allopurinol, antibiotics, anticonvulsants, and non-steroidal anti-inflammatory drugs (NSAIDs),...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1527051/full |
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| author | Yongguang Wang Yongguang Wang Qizheng Guo Qizheng Guo Zhenyang Li Zhenyang Li Guifen Gan Chun Pan |
| author_facet | Yongguang Wang Yongguang Wang Qizheng Guo Qizheng Guo Zhenyang Li Zhenyang Li Guifen Gan Chun Pan |
| author_sort | Yongguang Wang |
| collection | DOAJ |
| description | Toxic Epidermal Necrolysis (TEN) is a severe skin-mucosal reaction induced by medications, commonly characterized by blister formation and widespread epidermal detachment. Typical causative agents include allopurinol, antibiotics, anticonvulsants, and non-steroidal anti-inflammatory drugs (NSAIDs), with trimethoprim/sulfamethoxazole and penicillin being the most frequently implicated among antibiotics. However, lincosamide antibiotics as the cause of aggravation are rarely reported in clinical settings. This case report presents a patient with TEN induced by quinolone antibiotics, who experienced rapid progression of the condition after combining with lincomycin antibiotics. Clinical remission was achieved through a combination of corticosteroids, intravenous immunoglobulin, and plasma exchange therapy. This report aims to enhance clinicians’ understanding of TEN by providing a detailed case presentation and discussion. |
| format | Article |
| id | doaj-art-dce6319676d645aeb734005ea47809db |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-dce6319676d645aeb734005ea47809db2025-02-03T05:11:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15270511527051Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case reportYongguang Wang0Yongguang Wang1Qizheng Guo2Qizheng Guo3Zhenyang Li4Zhenyang Li5Guifen Gan6Chun Pan7Graduate School of Clinical Medicine, Qinghai University, Xining, ChinaDepartment of Intensive Care Medicine, Affiliated Hospital of Qinghai University, Xining, ChinaGraduate School of Clinical Medicine, Qinghai University, Xining, ChinaDepartment of Intensive Care Medicine, Affiliated Hospital of Qinghai University, Xining, ChinaGraduate School of Clinical Medicine, Qinghai University, Xining, ChinaDepartment of Intensive Care Medicine, Affiliated Hospital of Qinghai University, Xining, ChinaDepartment of Intensive Care Medicine, Affiliated Hospital of Qinghai University, Xining, ChinaDepartment of Intensive Care Unit, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaToxic Epidermal Necrolysis (TEN) is a severe skin-mucosal reaction induced by medications, commonly characterized by blister formation and widespread epidermal detachment. Typical causative agents include allopurinol, antibiotics, anticonvulsants, and non-steroidal anti-inflammatory drugs (NSAIDs), with trimethoprim/sulfamethoxazole and penicillin being the most frequently implicated among antibiotics. However, lincosamide antibiotics as the cause of aggravation are rarely reported in clinical settings. This case report presents a patient with TEN induced by quinolone antibiotics, who experienced rapid progression of the condition after combining with lincomycin antibiotics. Clinical remission was achieved through a combination of corticosteroids, intravenous immunoglobulin, and plasma exchange therapy. This report aims to enhance clinicians’ understanding of TEN by providing a detailed case presentation and discussion.https://www.frontiersin.org/articles/10.3389/fmed.2025.1527051/fulltoxic epidermal necrolysislincosamide antibioticscorticosteroidsintravenous immunoglobulinplasma exchange |
| spellingShingle | Yongguang Wang Yongguang Wang Qizheng Guo Qizheng Guo Zhenyang Li Zhenyang Li Guifen Gan Chun Pan Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report Frontiers in Medicine toxic epidermal necrolysis lincosamide antibiotics corticosteroids intravenous immunoglobulin plasma exchange |
| title | Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report |
| title_full | Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report |
| title_fullStr | Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report |
| title_full_unstemmed | Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report |
| title_short | Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report |
| title_sort | toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient a case report |
| topic | toxic epidermal necrolysis lincosamide antibiotics corticosteroids intravenous immunoglobulin plasma exchange |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1527051/full |
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