Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus
Multiple sclerosis (MS) is a neurological disease characterized by immune dysregulations. Different viruses may act as MS triggering agents. MS patients respond differently to distinct viruses. The aim of our study is to verify the association between the polyomavirus BKPyV and MS, together with oth...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/4864950 |
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| author | Ilaria Bononi Elisa Mazzoni Silvia Pietrobon Maria Rosa Iaquinta Andrea Caselli Elena Torreggiani Maura Pugliatti Ilaria Casetta Massimiliano Castellazzi Enrico Granieri Fernanda Martini Mauro Tognon |
| author_facet | Ilaria Bononi Elisa Mazzoni Silvia Pietrobon Maria Rosa Iaquinta Andrea Caselli Elena Torreggiani Maura Pugliatti Ilaria Casetta Massimiliano Castellazzi Enrico Granieri Fernanda Martini Mauro Tognon |
| author_sort | Ilaria Bononi |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a neurological disease characterized by immune dysregulations. Different viruses may act as MS triggering agents. MS patients respond differently to distinct viruses. The aim of our study is to verify the association between the polyomavirus BKPyV and MS, together with other neurological diseases, through the investigation of serum IgG antibodies against the virus. Sera were from patients affected by MS and other neurologic diseases, both inflammatory (OIND) and noninflammatory (NIND). Control sera were from healthy subjects (HS). Samples were analyzed for IgG antibodies against BKPyV with an indirect ELISA with synthetic peptides mimicking the viral capsid protein 1 (VP1) antigens. As control, ELISAs were carried out to verify the immune response against the Epstein-Barr virus (EBV) of patients and controls. In addition, we assessed values for total IgG in each experimental groups. A significant lower prevalence of IgG antibodies against BKPyV VP 1 epitopes, together with a low titer, was detected in sera from MS patients and other inflammatory neurologic diseases than HS. In MS patients and OIND and NIND groups, the EBV-antibody values and total IgG did not differ from HS. Experimental data indicate that patients affected by neurological diseases, including MS, are poor responders to BKPyV VP 1 antigens, thus suggesting specific immunologic dysfunctions for this polyomavirus. Our findings are relevant in understanding the immune reactions implicated in neurological disorders. |
| format | Article |
| id | doaj-art-dcde7f0a2ab442b392242b2353df0599 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-dcde7f0a2ab442b392242b2353df05992025-02-03T05:49:25ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/4864950Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human PolyomavirusIlaria Bononi0Elisa Mazzoni1Silvia Pietrobon2Maria Rosa Iaquinta3Andrea Caselli4Elena Torreggiani5Maura Pugliatti6Ilaria Casetta7Massimiliano Castellazzi8Enrico Granieri9Fernanda Martini10Mauro Tognon11Department of Translational Medicine and for RomagnaDepartment of ChemicalDepartment of Medical SciencesDepartment of Medical SciencesDepartment of Medical SciencesDepartment of Medical SciencesDepartment and Biomedical Sciences and Specialized SurgeriesDepartment and Biomedical Sciences and Specialized SurgeriesDepartment and Biomedical Sciences and Specialized SurgeriesDepartment and Biomedical Sciences and Specialized SurgeriesDepartment of Medical SciencesDepartment of Medical SciencesMultiple sclerosis (MS) is a neurological disease characterized by immune dysregulations. Different viruses may act as MS triggering agents. MS patients respond differently to distinct viruses. The aim of our study is to verify the association between the polyomavirus BKPyV and MS, together with other neurological diseases, through the investigation of serum IgG antibodies against the virus. Sera were from patients affected by MS and other neurologic diseases, both inflammatory (OIND) and noninflammatory (NIND). Control sera were from healthy subjects (HS). Samples were analyzed for IgG antibodies against BKPyV with an indirect ELISA with synthetic peptides mimicking the viral capsid protein 1 (VP1) antigens. As control, ELISAs were carried out to verify the immune response against the Epstein-Barr virus (EBV) of patients and controls. In addition, we assessed values for total IgG in each experimental groups. A significant lower prevalence of IgG antibodies against BKPyV VP 1 epitopes, together with a low titer, was detected in sera from MS patients and other inflammatory neurologic diseases than HS. In MS patients and OIND and NIND groups, the EBV-antibody values and total IgG did not differ from HS. Experimental data indicate that patients affected by neurological diseases, including MS, are poor responders to BKPyV VP 1 antigens, thus suggesting specific immunologic dysfunctions for this polyomavirus. Our findings are relevant in understanding the immune reactions implicated in neurological disorders.http://dx.doi.org/10.1155/2022/4864950 |
| spellingShingle | Ilaria Bononi Elisa Mazzoni Silvia Pietrobon Maria Rosa Iaquinta Andrea Caselli Elena Torreggiani Maura Pugliatti Ilaria Casetta Massimiliano Castellazzi Enrico Granieri Fernanda Martini Mauro Tognon Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus Journal of Immunology Research |
| title | Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus |
| title_full | Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus |
| title_fullStr | Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus |
| title_full_unstemmed | Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus |
| title_short | Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus |
| title_sort | neurological disease affected patients including multiple sclerosis are poor responders to bkpyv a human polyomavirus |
| url | http://dx.doi.org/10.1155/2022/4864950 |
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