Association between soft drinks consumption and asthma: a systematic review and meta-analysis
Objectives To carry out meta-analysis and systematic review on the association between soft drinks consumption and asthma prevalence among adults and children.Design Systematic review and meta-analysis of observational research.Data sources Medline, Scopus, ISI Web of Science and the Cochrane Librar...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/10/e029046.full |
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| author | Abdulmohsen Hamdan Al-Zalabani Ibrahim Noor Elahi Abdullah Katib Abdulmajeed G Alamri Abdulrahman Halawani Nasser M Alsindi Mohammed Almatrafi Anke Wesselius Kelly F J Stewart |
| author_facet | Abdulmohsen Hamdan Al-Zalabani Ibrahim Noor Elahi Abdullah Katib Abdulmajeed G Alamri Abdulrahman Halawani Nasser M Alsindi Mohammed Almatrafi Anke Wesselius Kelly F J Stewart |
| author_sort | Abdulmohsen Hamdan Al-Zalabani |
| collection | DOAJ |
| description | Objectives To carry out meta-analysis and systematic review on the association between soft drinks consumption and asthma prevalence among adults and children.Design Systematic review and meta-analysis of observational research.Data sources Medline, Scopus, ISI Web of Science and the Cochrane Library were searched up to December 2018.Eligibility criteria We included observational studies investigating the association between soft drinks consumption (including maternal consumption during pregnancy) and asthma or wheeze.Data extraction and synthesis Data were extracted by one author and reviewed independently by two other authors. The most adjusted estimate from each original study was used in the meta-analysis. Meta-analysis was conducted using random-effects model. The quality of studies was assessed using the Newcastle–Ottawa scale and heterogeneity was evaluated using I2 statistic.Results Of 725 publications originally identified, 19 were included in this systematic review, including 3 cohort studies and 16 cross-sectional studies. Ten articles reported on children up to 18 years, 5 articles on adults (>18 years) and 2 articles on prenatal exposure. In total, 468 836 participants were included, with more than 50 000 asthma cases. Soft drinks consumption was associated with significantly increased odds of asthma in both adults (OR=1.37; 95% CI, 1.23 to 1.52) and children (OR=1.14; 95% CI, 1.06 to 1.21). Prenatal exposure had marginally statistically significant association (OR=1.11; 95% CI, 1.00 to 1.23) with asthma in children. In subgroup analysis for childhood exposure, the association persists for sugar-sweetened soft drinks but not for carbonated drinks.Conclusion Our findings show a positive association between soft drinks consumption and asthma prevalence, mostly from cross-sectional studies. Therefore, more longitudinal research is required to establish causality. |
| format | Article |
| id | doaj-art-dcd1beadd00a463991ccf74404bb32bc |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-dcd1beadd00a463991ccf74404bb32bc2025-08-20T02:39:18ZengBMJ Publishing GroupBMJ Open2044-60552019-10-0191010.1136/bmjopen-2019-029046Association between soft drinks consumption and asthma: a systematic review and meta-analysisAbdulmohsen Hamdan Al-Zalabani0Ibrahim Noor Elahi1Abdullah Katib2Abdulmajeed G Alamri3Abdulrahman Halawani4Nasser M Alsindi5Mohammed Almatrafi6Anke Wesselius7Kelly F J Stewart81 Department of Family and Community Medicine, Taibah University, Madinah, Saudi Arabia2 Department of Family and Community Medicine, Taibah University, Joint Program of Community Medicine, Madinah, Saudi Arabia2 Department of Family and Community Medicine, Taibah University, Joint Program of Community Medicine, Madinah, Saudi Arabia2 Department of Family and Community Medicine, Taibah University, Joint Program of Community Medicine, Madinah, Saudi Arabia2 Department of Family and Community Medicine, Taibah University, Joint Program of Community Medicine, Madinah, Saudi Arabia2 Department of Family and Community Medicine, Taibah University, Joint Program of Community Medicine, Madinah, Saudi Arabia2 Department of Family and Community Medicine, Taibah University, Joint Program of Community Medicine, Madinah, Saudi Arabia9 NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands3 NUTRIM, Maastricht University, Maastricht, The NetherlandsObjectives To carry out meta-analysis and systematic review on the association between soft drinks consumption and asthma prevalence among adults and children.Design Systematic review and meta-analysis of observational research.Data sources Medline, Scopus, ISI Web of Science and the Cochrane Library were searched up to December 2018.Eligibility criteria We included observational studies investigating the association between soft drinks consumption (including maternal consumption during pregnancy) and asthma or wheeze.Data extraction and synthesis Data were extracted by one author and reviewed independently by two other authors. The most adjusted estimate from each original study was used in the meta-analysis. Meta-analysis was conducted using random-effects model. The quality of studies was assessed using the Newcastle–Ottawa scale and heterogeneity was evaluated using I2 statistic.Results Of 725 publications originally identified, 19 were included in this systematic review, including 3 cohort studies and 16 cross-sectional studies. Ten articles reported on children up to 18 years, 5 articles on adults (>18 years) and 2 articles on prenatal exposure. In total, 468 836 participants were included, with more than 50 000 asthma cases. Soft drinks consumption was associated with significantly increased odds of asthma in both adults (OR=1.37; 95% CI, 1.23 to 1.52) and children (OR=1.14; 95% CI, 1.06 to 1.21). Prenatal exposure had marginally statistically significant association (OR=1.11; 95% CI, 1.00 to 1.23) with asthma in children. In subgroup analysis for childhood exposure, the association persists for sugar-sweetened soft drinks but not for carbonated drinks.Conclusion Our findings show a positive association between soft drinks consumption and asthma prevalence, mostly from cross-sectional studies. Therefore, more longitudinal research is required to establish causality.https://bmjopen.bmj.com/content/9/10/e029046.full |
| spellingShingle | Abdulmohsen Hamdan Al-Zalabani Ibrahim Noor Elahi Abdullah Katib Abdulmajeed G Alamri Abdulrahman Halawani Nasser M Alsindi Mohammed Almatrafi Anke Wesselius Kelly F J Stewart Association between soft drinks consumption and asthma: a systematic review and meta-analysis BMJ Open |
| title | Association between soft drinks consumption and asthma: a systematic review and meta-analysis |
| title_full | Association between soft drinks consumption and asthma: a systematic review and meta-analysis |
| title_fullStr | Association between soft drinks consumption and asthma: a systematic review and meta-analysis |
| title_full_unstemmed | Association between soft drinks consumption and asthma: a systematic review and meta-analysis |
| title_short | Association between soft drinks consumption and asthma: a systematic review and meta-analysis |
| title_sort | association between soft drinks consumption and asthma a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/9/10/e029046.full |
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