A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific

A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific

Antigen-driven T-cell proliferation is often measured using fluorescent dye dilution assays, such as the CFSE-based proliferation assay. Dye dilution assays have been powerful tools to detect human CD4+ T-cell responses, particularly against autoantigens. However, it is not known how many cells with...

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Bibliographic Details
Main Authors: Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Chris Y. Chiu, Xin Liu, Eleonora Tresoldi, Abby Foster, Laura King, Fergus J. Cameron, Stuart I. Mannering
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
clonal expansion
proliferation
CD4+ T cell
autoimmunity
antigen specific T cell
C-peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491616/full
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