Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy
Abstract Background Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. Automated brain volumetry, widely used in human medicine, can now be applied in veterinary medicine because of the av...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.17237 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584147267223552 |
|---|---|
| author | Paulina Kinga Drobot Aleksandra Banasik Karolina Owsińska‐Schmidt Marcin Wrzosek Przemysław Podgórski |
| author_facet | Paulina Kinga Drobot Aleksandra Banasik Karolina Owsińska‐Schmidt Marcin Wrzosek Przemysław Podgórski |
| author_sort | Paulina Kinga Drobot |
| collection | DOAJ |
| description | Abstract Background Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. Automated brain volumetry, widely used in human medicine, can now be applied in veterinary medicine because of the availability of brain atlases. Objectives This study aimed to develop an automatic volumetry method, translate the outcomes into the assessment of temporal lobe volumes in dogs with idiopathic epilepsy, and correlate the results with the electroencephalography (EEG) data of epileptiform discharges (EDs). Animals Thirty‐one dogs of various breeds with dominant temporal lobe discharge. Methods Retrospective, observational study. The MRI and EEG examination results of dogs referred for neurological diagnosis data between 2016 and 2021 were retrospectively analyzed. An automated volumetry method was developed, which allowed the evaluation of temporal lobe volumes of the dogs. The asymmetric ratio (AR) was then estimated, and the results were correlated with the EEG EDs. Results 12/31 (38%; 95% CI: 21.8%‐57.8%) dogs had an asymmetric ratio >6%. Among them, reduction in temporal lobe volumes correlated with the side of the EEG EDs in 7 cases. There was no statistical correlation between temporal lobe volume changes and ED location. Conclusions and Clinical Importance Preliminary volumetric analysis of the temporal lobes indicates the presence of volume differences between the lobes in some dogs with idiopathic epilepsy. Diagnosis of TLE in dogs based on MRI volumetry in correlation with EEG examination, especially for dogs with drug‐resistant epilepsy, can influence the development of new therapeutic options, such as surgery. |
| format | Article |
| id | doaj-art-dcc8938ebcc7453eb68f2015c6b0adca |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-dcc8938ebcc7453eb68f2015c6b0adca2025-01-27T15:22:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17237Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsyPaulina Kinga Drobot0Aleksandra Banasik1Karolina Owsińska‐Schmidt2Marcin Wrzosek3Przemysław Podgórski4Department of Internal Medicine and Clinic for Horses, Dogs and Cats The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences Wroclaw PolandDepartment of Internal Medicine and Clinic for Horses, Dogs and Cats The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences Wroclaw PolandDepartment of Internal Medicine and Clinic for Horses, Dogs and Cats The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences Wroclaw PolandDepartment of Internal Medicine and Clinic for Horses, Dogs and Cats The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences Wroclaw PolandDivision of General and Interventional Radiology and Neuroradiology, Department of Radiology Faculty of Medicine, Wroclaw Medical University Wroclaw PolandAbstract Background Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. Automated brain volumetry, widely used in human medicine, can now be applied in veterinary medicine because of the availability of brain atlases. Objectives This study aimed to develop an automatic volumetry method, translate the outcomes into the assessment of temporal lobe volumes in dogs with idiopathic epilepsy, and correlate the results with the electroencephalography (EEG) data of epileptiform discharges (EDs). Animals Thirty‐one dogs of various breeds with dominant temporal lobe discharge. Methods Retrospective, observational study. The MRI and EEG examination results of dogs referred for neurological diagnosis data between 2016 and 2021 were retrospectively analyzed. An automated volumetry method was developed, which allowed the evaluation of temporal lobe volumes of the dogs. The asymmetric ratio (AR) was then estimated, and the results were correlated with the EEG EDs. Results 12/31 (38%; 95% CI: 21.8%‐57.8%) dogs had an asymmetric ratio >6%. Among them, reduction in temporal lobe volumes correlated with the side of the EEG EDs in 7 cases. There was no statistical correlation between temporal lobe volume changes and ED location. Conclusions and Clinical Importance Preliminary volumetric analysis of the temporal lobes indicates the presence of volume differences between the lobes in some dogs with idiopathic epilepsy. Diagnosis of TLE in dogs based on MRI volumetry in correlation with EEG examination, especially for dogs with drug‐resistant epilepsy, can influence the development of new therapeutic options, such as surgery.https://doi.org/10.1111/jvim.17237asymmetric ratiodogepileptiform dischargesmagnetic resonance imagingradiology and diagnostic imagingtemporal lobe epilepsy |
| spellingShingle | Paulina Kinga Drobot Aleksandra Banasik Karolina Owsińska‐Schmidt Marcin Wrzosek Przemysław Podgórski Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy Journal of Veterinary Internal Medicine asymmetric ratio dog epileptiform discharges magnetic resonance imaging radiology and diagnostic imaging temporal lobe epilepsy |
| title | Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy |
| title_full | Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy |
| title_fullStr | Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy |
| title_full_unstemmed | Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy |
| title_short | Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy |
| title_sort | semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy |
| topic | asymmetric ratio dog epileptiform discharges magnetic resonance imaging radiology and diagnostic imaging temporal lobe epilepsy |
| url | https://doi.org/10.1111/jvim.17237 |
| work_keys_str_mv | AT paulinakingadrobot semiautomaticvolumetryofthetemporallobesofthebrainandcorrelationwithelectroencephalographyresultsindogswithassumedidiopathicepilepsy AT aleksandrabanasik semiautomaticvolumetryofthetemporallobesofthebrainandcorrelationwithelectroencephalographyresultsindogswithassumedidiopathicepilepsy AT karolinaowsinskaschmidt semiautomaticvolumetryofthetemporallobesofthebrainandcorrelationwithelectroencephalographyresultsindogswithassumedidiopathicepilepsy AT marcinwrzosek semiautomaticvolumetryofthetemporallobesofthebrainandcorrelationwithelectroencephalographyresultsindogswithassumedidiopathicepilepsy AT przemysławpodgorski semiautomaticvolumetryofthetemporallobesofthebrainandcorrelationwithelectroencephalographyresultsindogswithassumedidiopathicepilepsy |