Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two‐Step, Two‐Sample Bidirectional Mendelian Randomization Study

ABSTRACT Background Some studies have shown that gut microbiota may be associated with intervertebral disc degeneration. However, the causal effects between gut microbiota and IVDD and whether blood metabolites act as a mediator remain unclear. The objective of this study was to investigate the caus...

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Main Authors: Yi‐Ping Zheng, Dong‐Lin Yang, Lu‐Yang Wang, Xi‐Zhong Zhu, Xing‐Chen Li, Jin‐Hong Miao, Yu‐Sheng Xu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:JOR Spine
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Online Access:https://doi.org/10.1002/jsp2.70078
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