A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.

A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.

Despite evidence of the clustering of metabolic syndrome components, current approaches for identifying unifying genetic mechanisms typically evaluate clinical categories that do not provide adequate etiological information. Here, we used data from 19,486 European American and 6,287 African American...

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Main Authors: Christy L Avery, Qianchuan He, Kari E North, Jose L Ambite, Eric Boerwinkle, Myriam Fornage, Lucia A Hindorff, Charles Kooperberg, James B Meigs, James S Pankow, Sarah A Pendergrass, Bruce M Psaty, Marylyn D Ritchie, Jerome I Rotter, Kent D Taylor, Lynne R Wilkens, Gerardo Heiss, Dan Yu Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002322&type=printable
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