Compromised PGF2α signaling in the paraventricular hypothalamic nucleus contributes to the central sensitization of the nitroglycerin-induced chronic migraine in male mice

Compromised PGF2α signaling in the paraventricular hypothalamic nucleus contributes to the central sensitization of the nitroglycerin-induced chronic migraine in male mice

Abstract Impaired descending inhibitory controls are now understood to exacerbate central sensitization of chronic migraine, yet the underlying neural and molecular mechanisms remain largely elusive. Herein, a paraventricular hypothalamic nucleus (PVN) oxytocin (OXT) → trigeminal nucleus caudalis (T...

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Bibliographic Details
Main Authors: Xianrong Hu, Lunquan Wu, Li Wang, Congxue Peng, Yunyun Tian, Qian Zhu, Hongwei Zhu, Liang Nie, Li Yin, Yuehui Zhang, Jiang Bian
Format: Article
Language:English
Published: BMC 2025-08-01
Series:The Journal of Headache and Pain
Subjects:
Chronic migraine
Central sensitization
PGF2α signaling
Descending pain modulation
Online Access:https://doi.org/10.1186/s10194-025-02124-x
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