Emerging roles of exosomal circRNAs in non-small cell lung cancer
Abstract Despite the prevalence of non-small cell lung cancer (NSCLC) is high, the limited early detection and management of these tumors are restricted since there is an absence of reliable and precise diagnostic biomarkers and therapeutic targets. Exosomes transport functional molecules for facili...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06463-w |
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| author | Hongyuan Yin Jiayi Shi Shaoling Li Qianhui You Huici Zhu Chinying Koo Baonian Liu Likun Hou Chunyan Wu |
| author_facet | Hongyuan Yin Jiayi Shi Shaoling Li Qianhui You Huici Zhu Chinying Koo Baonian Liu Likun Hou Chunyan Wu |
| author_sort | Hongyuan Yin |
| collection | DOAJ |
| description | Abstract Despite the prevalence of non-small cell lung cancer (NSCLC) is high, the limited early detection and management of these tumors are restricted since there is an absence of reliable and precise diagnostic biomarkers and therapeutic targets. Exosomes transport functional molecules for facilitating intercellular communication, especially in the tumor microenvironment, indicating their potential as cancer biomarkers and therapeutic targets. Circular RNA (circRNA), a type of non-coding RNA possessing a covalently closed loop structure, substantial abundance, and tissue-specific expression patterns, is stably enriched in exosomes. In recent years, significant breakthroughs have been made in research on exosomal circRNA in NSCLC. This review briefly introduces the biogenesis, characterizations, and functions of circRNAs and exosomes, and systematically describes the biological functions and mechanisms of exosomal circRNAs in NSCLC. In addition, this study summarizes their role in the progression of NSCLC and discusses their clinical significance as biomarkers and therapeutic targets for NSCLC. |
| format | Article |
| id | doaj-art-dca02cdf6bf444e7879ed272556c4d1c |
| institution | OA Journals |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-dca02cdf6bf444e7879ed272556c4d1c2025-08-20T02:10:49ZengBMCJournal of Translational Medicine1479-58762025-04-0123111810.1186/s12967-025-06463-wEmerging roles of exosomal circRNAs in non-small cell lung cancerHongyuan Yin0Jiayi Shi1Shaoling Li2Qianhui You3Huici Zhu4Chinying Koo5Baonian Liu6Likun Hou7Chunyan Wu8Department of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityAbstract Despite the prevalence of non-small cell lung cancer (NSCLC) is high, the limited early detection and management of these tumors are restricted since there is an absence of reliable and precise diagnostic biomarkers and therapeutic targets. Exosomes transport functional molecules for facilitating intercellular communication, especially in the tumor microenvironment, indicating their potential as cancer biomarkers and therapeutic targets. Circular RNA (circRNA), a type of non-coding RNA possessing a covalently closed loop structure, substantial abundance, and tissue-specific expression patterns, is stably enriched in exosomes. In recent years, significant breakthroughs have been made in research on exosomal circRNA in NSCLC. This review briefly introduces the biogenesis, characterizations, and functions of circRNAs and exosomes, and systematically describes the biological functions and mechanisms of exosomal circRNAs in NSCLC. In addition, this study summarizes their role in the progression of NSCLC and discusses their clinical significance as biomarkers and therapeutic targets for NSCLC.https://doi.org/10.1186/s12967-025-06463-wExosomal circRNAsNon-small cell lung cancerExosomesCircRNAsBiomarkerTherapeutic target |
| spellingShingle | Hongyuan Yin Jiayi Shi Shaoling Li Qianhui You Huici Zhu Chinying Koo Baonian Liu Likun Hou Chunyan Wu Emerging roles of exosomal circRNAs in non-small cell lung cancer Journal of Translational Medicine Exosomal circRNAs Non-small cell lung cancer Exosomes CircRNAs Biomarker Therapeutic target |
| title | Emerging roles of exosomal circRNAs in non-small cell lung cancer |
| title_full | Emerging roles of exosomal circRNAs in non-small cell lung cancer |
| title_fullStr | Emerging roles of exosomal circRNAs in non-small cell lung cancer |
| title_full_unstemmed | Emerging roles of exosomal circRNAs in non-small cell lung cancer |
| title_short | Emerging roles of exosomal circRNAs in non-small cell lung cancer |
| title_sort | emerging roles of exosomal circrnas in non small cell lung cancer |
| topic | Exosomal circRNAs Non-small cell lung cancer Exosomes CircRNAs Biomarker Therapeutic target |
| url | https://doi.org/10.1186/s12967-025-06463-w |
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