The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa

The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa

Abstract Specialized DNA polymerases facilitate various cellular processes. Despite extensive research, the mutagenic effects of these error-prone enzymes on genomes are not fully understood. Here we show that Pol IV promotes genomic instability in Pseudomonas aeruginosa by misincorporating oxidized...

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Bibliographic Details
Main Authors: Sofía D. Castell, Consuelo M. Fernandez, Ignacio N. Tumas, Lucía M. Margara, María C. Miserendino, Danilo G. Ceschin, Roberto J. Pezza, Mariela R. Monti
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08589-5
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