Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword
Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiological processes, including cancer. Ligands for PPARγ include na...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/362085 |
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| _version_ | 1832547605602631680 |
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| author | Howard Li Mary C. M. Weiser-Evans Raphael Nemenoff |
| author_facet | Howard Li Mary C. M. Weiser-Evans Raphael Nemenoff |
| author_sort | Howard Li |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiological processes, including cancer. Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione class of antidiabetic drugs. Activation of PPARγ in a variety of cancer cells leads to inhibition of growth, decreased invasiveness, reduced production of proinflammatory cytokines, and promotion of a more differentiated phenotype. However, systemic activation of PPARγ has been reported to be protumorigenic in some in vitro systems and in vivo models. Here, we review the available data that implicate PPARγ in lung carcinogenesis and highlight the challenges of targeting PPARγ in lung cancer treatments. |
| format | Article |
| id | doaj-art-dc7a1d3814c740b981656fbf96f1fa6f |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-dc7a1d3814c740b981656fbf96f1fa6f2025-02-03T06:44:19ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/362085362085Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged SwordHoward Li0Mary C. M. Weiser-Evans1Raphael Nemenoff2Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USADivision of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USADivision of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USAPeroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiological processes, including cancer. Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione class of antidiabetic drugs. Activation of PPARγ in a variety of cancer cells leads to inhibition of growth, decreased invasiveness, reduced production of proinflammatory cytokines, and promotion of a more differentiated phenotype. However, systemic activation of PPARγ has been reported to be protumorigenic in some in vitro systems and in vivo models. Here, we review the available data that implicate PPARγ in lung carcinogenesis and highlight the challenges of targeting PPARγ in lung cancer treatments.http://dx.doi.org/10.1155/2012/362085 |
| spellingShingle | Howard Li Mary C. M. Weiser-Evans Raphael Nemenoff Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword PPAR Research |
| title | Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword |
| title_full | Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword |
| title_fullStr | Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword |
| title_full_unstemmed | Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword |
| title_short | Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword |
| title_sort | anti and protumorigenic effects of pparγ in lung cancer progression a double edged sword |
| url | http://dx.doi.org/10.1155/2012/362085 |
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