Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern
Fibrolamellar carcinoma (FLC) is an uncommon form of primary liver malignancy with unique clinical, histological, and biological characteristics. It is usually seen in young adults without underlying liver disease. Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesi...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/609780 |
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| author | Diana Castro-Villabón Luis E. Barrera-Herrera Paula A. Rodríguez-Urrego Rachel Hudacko Alonso Vera Johanna Álvarez Rafael Andrade Rocío López |
| author_facet | Diana Castro-Villabón Luis E. Barrera-Herrera Paula A. Rodríguez-Urrego Rachel Hudacko Alonso Vera Johanna Álvarez Rafael Andrade Rocío López |
| author_sort | Diana Castro-Villabón |
| collection | DOAJ |
| description | Fibrolamellar carcinoma (FLC) is an uncommon form of primary liver malignancy with unique clinical, histological, and biological characteristics. It is usually seen in young adults without underlying liver disease. Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesicular nuclei, prominent nucleoli, and lamellar type fibrosis. In contrast, classical hepatocellular carcinoma (HCC) is typically present in elderly male patients with cirrhosis. It is the most common histological subtype, and it is characterized by its resemblance to the normal liver, both in its growth pattern and its cytology. The unusual case of a liver carcinoma that presented with histological features of both FLC and classical HCC is herein reported. This was the case of a 37-year-old female complaining of diffuse abdominal discomfort and epigastric pain for two months. She was referred to us for further management after she was diagnosed with HCC in a noncirrhotic liver. She underwent a left-sided hepatectomy. A yellow nodular mass with well-defined borders and a necrotic center was present in the resection specimen. The morphological features and immunohistochemical studies were consistent with a diagnosis of FLC mixed with classical HCC. The patient was followed up for five months, and no signs of recurrence were evident. |
| format | Article |
| id | doaj-art-dc7377bfc980444d8907e5ab4ad20b97 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-dc7377bfc980444d8907e5ab4ad20b972025-02-03T01:29:17ZengWileyCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/609780609780Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological PatternDiana Castro-Villabón0Luis E. Barrera-Herrera1Paula A. Rodríguez-Urrego2Rachel Hudacko3Alonso Vera4Johanna Álvarez5Rafael Andrade6Rocío López7Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaDepartment of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaDepartment of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaDepartment of Pathology, Good Samaritan Regional Medical Center, 255 Lafayette Avenue, Suffern, NY 10901, USATransplant and Hepatobiliary Surgical Service, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaDepartment of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaDepartment of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaDepartment of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, ColombiaFibrolamellar carcinoma (FLC) is an uncommon form of primary liver malignancy with unique clinical, histological, and biological characteristics. It is usually seen in young adults without underlying liver disease. Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesicular nuclei, prominent nucleoli, and lamellar type fibrosis. In contrast, classical hepatocellular carcinoma (HCC) is typically present in elderly male patients with cirrhosis. It is the most common histological subtype, and it is characterized by its resemblance to the normal liver, both in its growth pattern and its cytology. The unusual case of a liver carcinoma that presented with histological features of both FLC and classical HCC is herein reported. This was the case of a 37-year-old female complaining of diffuse abdominal discomfort and epigastric pain for two months. She was referred to us for further management after she was diagnosed with HCC in a noncirrhotic liver. She underwent a left-sided hepatectomy. A yellow nodular mass with well-defined borders and a necrotic center was present in the resection specimen. The morphological features and immunohistochemical studies were consistent with a diagnosis of FLC mixed with classical HCC. The patient was followed up for five months, and no signs of recurrence were evident.http://dx.doi.org/10.1155/2015/609780 |
| spellingShingle | Diana Castro-Villabón Luis E. Barrera-Herrera Paula A. Rodríguez-Urrego Rachel Hudacko Alonso Vera Johanna Álvarez Rafael Andrade Rocío López Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern Case Reports in Pathology |
| title | Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern |
| title_full | Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern |
| title_fullStr | Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern |
| title_full_unstemmed | Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern |
| title_short | Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern |
| title_sort | hepatocellular carcinoma with both fibrolamellar and classical components an unusual morphological pattern |
| url | http://dx.doi.org/10.1155/2015/609780 |
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