Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis
Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that the mucosal adhesion properties of hydrogels can play a potential role in the treatment of periodontitis. The...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425002704 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850064024160436224 |
|---|---|
| author | Yi Quan Huihui Shao Nuoya Wang Zhonggao Gao Mingji Jin |
| author_facet | Yi Quan Huihui Shao Nuoya Wang Zhonggao Gao Mingji Jin |
| author_sort | Yi Quan |
| collection | DOAJ |
| description | Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that the mucosal adhesion properties of hydrogels can play a potential role in the treatment of periodontitis. The hydrogel can improve the contact and retention time of drugs in the periodontal pocket. Through the adhesion of mucosa, it interacts with the mucin coating surface of epithelium and teeth to form a specific interface force. The hydrogel exhibits strong mucosal adhesion (adhesion strength: 5–6 N/cm2) and prolonged retention in periodontal pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH and reactive oxygen species (ROS). This design overcomes the limitations of poor mechanical stability in conventional formulations. The dynamic balance of oral microbiota plays an important role in maintaining oral health. Probiotics, by colonizing the oral cavity, transform the infected site from an environment rich in inflammatory cytokines to a more benign environment, inhibit harmful pathogenic microorganisms, and contribute to overall health. Microenvironment sensitive hydrogels can perform dynamic sol gel transformation in situ, and can accurately control drug release when exposed to various stimuli (such as temperature change, light, pH change, reactive oxygen species, etc.). Oral probiotics and anti-inflammatory drugs are encapsulated in hydrogels to inhibit the proliferation and adhesion of oral pathogens by planting in the mouth and producing metabolites, effectively preventing and treating oral diseases. |
| format | Article |
| id | doaj-art-dc6bb8e44f0742cc8ffd8c47efc81feb |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-dc6bb8e44f0742cc8ffd8c47efc81feb2025-08-20T02:49:25ZengElsevierMaterials Today Bio2590-00642025-06-013210171110.1016/j.mtbio.2025.101711Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitisYi Quan0Huihui Shao1Nuoya Wang2Zhonggao Gao3Mingji Jin4Peking University People's Hospital, Beijing, 100044, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Corresponding author. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Corresponding author. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that the mucosal adhesion properties of hydrogels can play a potential role in the treatment of periodontitis. The hydrogel can improve the contact and retention time of drugs in the periodontal pocket. Through the adhesion of mucosa, it interacts with the mucin coating surface of epithelium and teeth to form a specific interface force. The hydrogel exhibits strong mucosal adhesion (adhesion strength: 5–6 N/cm2) and prolonged retention in periodontal pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH and reactive oxygen species (ROS). This design overcomes the limitations of poor mechanical stability in conventional formulations. The dynamic balance of oral microbiota plays an important role in maintaining oral health. Probiotics, by colonizing the oral cavity, transform the infected site from an environment rich in inflammatory cytokines to a more benign environment, inhibit harmful pathogenic microorganisms, and contribute to overall health. Microenvironment sensitive hydrogels can perform dynamic sol gel transformation in situ, and can accurately control drug release when exposed to various stimuli (such as temperature change, light, pH change, reactive oxygen species, etc.). Oral probiotics and anti-inflammatory drugs are encapsulated in hydrogels to inhibit the proliferation and adhesion of oral pathogens by planting in the mouth and producing metabolites, effectively preventing and treating oral diseases.http://www.sciencedirect.com/science/article/pii/S2590006425002704PeriodontitisMicrobial floraProbioticsAnti-inflammatory drugsHydrogel |
| spellingShingle | Yi Quan Huihui Shao Nuoya Wang Zhonggao Gao Mingji Jin Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis Materials Today Bio Periodontitis Microbial flora Probiotics Anti-inflammatory drugs Hydrogel |
| title | Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis |
| title_full | Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis |
| title_fullStr | Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis |
| title_full_unstemmed | Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis |
| title_short | Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis |
| title_sort | microenvironment sensitive hydrogels as promising drug delivery systems for co encapsulating microbial homeostasis probiotics and anti inflammatory drugs to treat periodontitis |
| topic | Periodontitis Microbial flora Probiotics Anti-inflammatory drugs Hydrogel |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425002704 |
| work_keys_str_mv | AT yiquan microenvironmentsensitivehydrogelsaspromisingdrugdeliverysystemsforcoencapsulatingmicrobialhomeostasisprobioticsandantiinflammatorydrugstotreatperiodontitis AT huihuishao microenvironmentsensitivehydrogelsaspromisingdrugdeliverysystemsforcoencapsulatingmicrobialhomeostasisprobioticsandantiinflammatorydrugstotreatperiodontitis AT nuoyawang microenvironmentsensitivehydrogelsaspromisingdrugdeliverysystemsforcoencapsulatingmicrobialhomeostasisprobioticsandantiinflammatorydrugstotreatperiodontitis AT zhonggaogao microenvironmentsensitivehydrogelsaspromisingdrugdeliverysystemsforcoencapsulatingmicrobialhomeostasisprobioticsandantiinflammatorydrugstotreatperiodontitis AT mingjijin microenvironmentsensitivehydrogelsaspromisingdrugdeliverysystemsforcoencapsulatingmicrobialhomeostasisprobioticsandantiinflammatorydrugstotreatperiodontitis |