Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study

Chronic hepatitis B virus (HBV) infection affects 257–291 million people worldwide. The World Health Organization reported 890,000 HBV-related deaths in 2019, higher than reported previously. There are 10 HBV genotypes (A–J) subdivided into several subgenotypes that differ considerably by geography....

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Main Authors: Miguel Moncayo, Enrique Teran, Bernardo Gutierrez, Jorge Reyes, Johanna Cortez, Rodrigo Tobar, Gabriela Yerovi, Marcia Robalino, Ana Aguilar, Daniel Garzon-Chavez
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advances in Virology
Online Access:http://dx.doi.org/10.1155/2024/8823341
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author Miguel Moncayo
Enrique Teran
Bernardo Gutierrez
Jorge Reyes
Johanna Cortez
Rodrigo Tobar
Gabriela Yerovi
Marcia Robalino
Ana Aguilar
Daniel Garzon-Chavez
author_facet Miguel Moncayo
Enrique Teran
Bernardo Gutierrez
Jorge Reyes
Johanna Cortez
Rodrigo Tobar
Gabriela Yerovi
Marcia Robalino
Ana Aguilar
Daniel Garzon-Chavez
author_sort Miguel Moncayo
collection DOAJ
description Chronic hepatitis B virus (HBV) infection affects 257–291 million people worldwide. The World Health Organization reported 890,000 HBV-related deaths in 2019, higher than reported previously. There are 10 HBV genotypes (A–J) subdivided into several subgenotypes that differ considerably by geography. Various virologic factors, including genotype and subgenotype, impact the odds of acquiring a chronic HBV infection, the type of treatment prescribed, and the risk of developing hepatocarcinoma. Information on the HBV genotypes and subgenotypes that circulate in Ecuador remains low. To address this gap, the current study took a preliminary look at HBV-infected human samples from this region to identify the most common genotypes and subgenotypes. Samples from 44 patients in the Andean, Coastal, and Amazon regions of Ecuador were amplified and two major genotypes were identified, genotype F (42/44; 95.5%) and genotype E (2 patients; 4.5%). The genotype F subgenotypes were F3 (35/42; 83.33%), F4 (6/42; 14.28%), and F1b (1/42, 2.39%). This is the first epidemiological study to assess the distribution of HBV genotypes in Ecuador. The findings can inform antiviral drug effectivity studies specific to HBV genotypes prevalent in South America.
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spelling doaj-art-dc6b0a075d2c41848a16be785ede91842025-02-03T11:40:37ZengWileyAdvances in Virology1687-86472024-01-01202410.1155/2024/8823341Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary StudyMiguel Moncayo0Enrique Teran1Bernardo Gutierrez2Jorge Reyes3Johanna Cortez4Rodrigo Tobar5Gabriela Yerovi6Marcia Robalino7Ana Aguilar8Daniel Garzon-Chavez9Universidad San Francisco de Quito USFQUniversidad San Francisco de Quito USFQUniversidad San Francisco de Quito USFQUniversidad Central del EcuadorLaboratorio Clínico Dr. Alberto Moncayo CaleroMinisterio de Salud Pública del EcuadorMinisterio de Salud Pública del EcuadorMinisterio de Salud Pública del EcuadorUniversidad San Francisco de Quito USFQUniversidad San Francisco de Quito USFQChronic hepatitis B virus (HBV) infection affects 257–291 million people worldwide. The World Health Organization reported 890,000 HBV-related deaths in 2019, higher than reported previously. There are 10 HBV genotypes (A–J) subdivided into several subgenotypes that differ considerably by geography. Various virologic factors, including genotype and subgenotype, impact the odds of acquiring a chronic HBV infection, the type of treatment prescribed, and the risk of developing hepatocarcinoma. Information on the HBV genotypes and subgenotypes that circulate in Ecuador remains low. To address this gap, the current study took a preliminary look at HBV-infected human samples from this region to identify the most common genotypes and subgenotypes. Samples from 44 patients in the Andean, Coastal, and Amazon regions of Ecuador were amplified and two major genotypes were identified, genotype F (42/44; 95.5%) and genotype E (2 patients; 4.5%). The genotype F subgenotypes were F3 (35/42; 83.33%), F4 (6/42; 14.28%), and F1b (1/42, 2.39%). This is the first epidemiological study to assess the distribution of HBV genotypes in Ecuador. The findings can inform antiviral drug effectivity studies specific to HBV genotypes prevalent in South America.http://dx.doi.org/10.1155/2024/8823341
spellingShingle Miguel Moncayo
Enrique Teran
Bernardo Gutierrez
Jorge Reyes
Johanna Cortez
Rodrigo Tobar
Gabriela Yerovi
Marcia Robalino
Ana Aguilar
Daniel Garzon-Chavez
Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study
Advances in Virology
title Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study
title_full Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study
title_fullStr Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study
title_full_unstemmed Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study
title_short Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study
title_sort hepatitis b virus hbv genotypes in an ecuadorian population a preliminary study
url http://dx.doi.org/10.1155/2024/8823341
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