In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity
Several extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatme...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5457010 |
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| author | Gianandrea Guidetti Alessandro Di Cerbo Angela Giovazzino Valentina Rubino Anna Teresa Palatucci Sara Centenaro Elena Fraccaroli Laura Cortese Maria Grazia Bonomo Giuseppina Ruggiero Sergio Canello Giuseppe Terrazzano |
| author_facet | Gianandrea Guidetti Alessandro Di Cerbo Angela Giovazzino Valentina Rubino Anna Teresa Palatucci Sara Centenaro Elena Fraccaroli Laura Cortese Maria Grazia Bonomo Giuseppina Ruggiero Sergio Canello Giuseppe Terrazzano |
| author_sort | Gianandrea Guidetti |
| collection | DOAJ |
| description | Several extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatment in broiler chickens, was reported in chicken edible tissues and could represent a potential risk for pets and humans that could assume this antibiotic as residue in meat or in meat-derived byproducts. We investigated the in vitro anti-inflammatory properties of a pool of thirteen botanicals as a part of a nutraceutical diet, with proven immunomodulatory activity. In addition, we evaluated the effect of such botanicals in contrasting the in vitro proinflammatory toxicity of OTC. Our results showed a significant reduction in interferon- (INF-) γ production by human and canine lymphocytes in presence of botanicals (p⁎<0.05). Increased INF-γ production, dependent on 24-hour OTC-incubation of T lymphocytes, was significantly reduced by the coincubation with Haematococcus pluvialis, with Glycine max, and with the mix of all botanicals (p⁎<0.05). In conclusion, the use of these botanicals was shown to be able to contrast OTC-toxicity and could represent a new approach for the development of functional foods useful to enhance the standard pharmacological treatment in infections as well as in preventing or reducing the emergence of inflammatory diseases. |
| format | Article |
| id | doaj-art-dc5ed120395547d585d4a4e3025ff23b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-dc5ed120395547d585d4a4e3025ff23b2025-02-03T01:33:05ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/54570105457010In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic ActivityGianandrea Guidetti0Alessandro Di Cerbo1Angela Giovazzino2Valentina Rubino3Anna Teresa Palatucci4Sara Centenaro5Elena Fraccaroli6Laura Cortese7Maria Grazia Bonomo8Giuseppina Ruggiero9Sergio Canello10Giuseppe Terrazzano11Division of Research and Development, SANYpet SpA, 35023 Bagnoli di Sopra, ItalySchool of Specialization in Clinical Biochemistry, “G. d’Annunzio” University, 66100 Chieti, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyPh.D. School of Science, University of Basilicata, 85100 Potenza, ItalyDivision of Research and Development, SANYpet SpA, 35023 Bagnoli di Sopra, ItalyDivision of Research and Development, SANYpet SpA, 35023 Bagnoli di Sopra, ItalyDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80100 Naples, ItalyDepartment of Science, University of Basilicata, 85100 Potenza, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDivision of Research and Development, SANYpet SpA, 35023 Bagnoli di Sopra, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalySeveral extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatment in broiler chickens, was reported in chicken edible tissues and could represent a potential risk for pets and humans that could assume this antibiotic as residue in meat or in meat-derived byproducts. We investigated the in vitro anti-inflammatory properties of a pool of thirteen botanicals as a part of a nutraceutical diet, with proven immunomodulatory activity. In addition, we evaluated the effect of such botanicals in contrasting the in vitro proinflammatory toxicity of OTC. Our results showed a significant reduction in interferon- (INF-) γ production by human and canine lymphocytes in presence of botanicals (p⁎<0.05). Increased INF-γ production, dependent on 24-hour OTC-incubation of T lymphocytes, was significantly reduced by the coincubation with Haematococcus pluvialis, with Glycine max, and with the mix of all botanicals (p⁎<0.05). In conclusion, the use of these botanicals was shown to be able to contrast OTC-toxicity and could represent a new approach for the development of functional foods useful to enhance the standard pharmacological treatment in infections as well as in preventing or reducing the emergence of inflammatory diseases.http://dx.doi.org/10.1155/2016/5457010 |
| spellingShingle | Gianandrea Guidetti Alessandro Di Cerbo Angela Giovazzino Valentina Rubino Anna Teresa Palatucci Sara Centenaro Elena Fraccaroli Laura Cortese Maria Grazia Bonomo Giuseppina Ruggiero Sergio Canello Giuseppe Terrazzano In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity Journal of Immunology Research |
| title | In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity |
| title_full | In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity |
| title_fullStr | In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity |
| title_full_unstemmed | In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity |
| title_short | In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity |
| title_sort | in vitro effects of some botanicals with anti inflammatory and antitoxic activity |
| url | http://dx.doi.org/10.1155/2016/5457010 |
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