Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions
Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in th...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/618658 |
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| author | Adil Mardinoglu P. J. Cregg |
| author_facet | Adil Mardinoglu P. J. Cregg |
| author_sort | Adil Mardinoglu |
| collection | DOAJ |
| description | Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications. |
| format | Article |
| id | doaj-art-dc5d00589707469b9c976a9d24722edb |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-dc5d00589707469b9c976a9d24722edb2025-02-03T01:10:38ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/618658618658Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle InteractionsAdil Mardinoglu0P. J. Cregg1Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, SwedenMaterials Characterisation & Processing Group, Waterford Institute of Technology, Waterford, IrelandCancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications.http://dx.doi.org/10.1155/2015/618658 |
| spellingShingle | Adil Mardinoglu P. J. Cregg Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions The Scientific World Journal |
| title | Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions |
| title_full | Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions |
| title_fullStr | Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions |
| title_full_unstemmed | Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions |
| title_short | Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions |
| title_sort | modelling the effect of spion size in a stent assisted magnetic drug targeting system with interparticle interactions |
| url | http://dx.doi.org/10.1155/2015/618658 |
| work_keys_str_mv | AT adilmardinoglu modellingtheeffectofspionsizeinastentassistedmagneticdrugtargetingsystemwithinterparticleinteractions AT pjcregg modellingtheeffectofspionsizeinastentassistedmagneticdrugtargetingsystemwithinterparticleinteractions |