Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study
Introduction. Immunodeficiencies are disturbances in the immune system that can affect cell function, quantity, or both. They can be either primary, associated with genetic defects, or secondary, linked to external factors such as hemato-oncological conditions. Secondary immunodeficiencies can lead...
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Instituto Nacional de Salud
2024-12-01
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| Series: | Biomédica: revista del Instituto Nacional de Salud |
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| Online Access: | https://revistabiomedica.org/index.php/biomedica/article/view/7584 |
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| author | Ana Lucía Guzmán Isabella Villamil Sofía Martínez-Betancur Oriana Arias-Valderrama Jacobo Triviño-Arias Jessica Largo Viviana Lotero Alexis Franco Ximena Castro Pamela Rodríguez Luz Angela Urcuqui Diego Medina Manuela Olaya |
| author_facet | Ana Lucía Guzmán Isabella Villamil Sofía Martínez-Betancur Oriana Arias-Valderrama Jacobo Triviño-Arias Jessica Largo Viviana Lotero Alexis Franco Ximena Castro Pamela Rodríguez Luz Angela Urcuqui Diego Medina Manuela Olaya |
| author_sort | Ana Lucía Guzmán |
| collection | DOAJ |
| description | Introduction. Immunodeficiencies are disturbances in the immune system that can affect cell function, quantity, or both. They can be either primary, associated with genetic defects, or secondary, linked to external factors such as hemato-oncological conditions. Secondary immunodeficiencies can lead to the initiation, reactivation, or acceleration of latent, residual, or active infections, which are the leading cause of mortality.
Objective. To elucidate the occurrence and clinical characteristics of hypogammaglobulinemia in pediatric oncology patients in a high-complexity hospital in
Colombia between January 2020 and December 2022.
Materials and methods. We conducted an observational study with patients under 18 years old with a cancer diagnosis, serum immunoglobulins measurements at the time of the diagnosis, and later follow-up during treatment.
Results. We included 133 patients with a median age of eight years. Based on local guidelines of immunoglobulin levels for age, all patients had normal values at the time of cancer diagnosis. In the follow-up, the most significant reduction among all ages was for IgA and was related to infections and death.
Conclusions. Our findings highlight the importance of measuring immunoglobulin levels at the time of the cancer diagnosis, as hypogammaglobulinemia may be linked to a poorer prognosis. Early detection could potentially improve patient outcomes. |
| format | Article |
| id | doaj-art-dc5c5b4a41ca406985fb22d31b68b637 |
| institution | Kabale University |
| issn | 0120-4157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Biomédica: revista del Instituto Nacional de Salud |
| spelling | doaj-art-dc5c5b4a41ca406985fb22d31b68b6372025-01-21T18:56:10ZengInstituto Nacional de SaludBiomédica: revista del Instituto Nacional de Salud0120-41572024-12-0144Sp. 219119710.7705/biomedica.75849039Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort studyAna Lucía Guzmán0https://orcid.org/0009-0005-2673-9545Isabella Villamil1https://orcid.org/0009-0002-0960-1649Sofía Martínez-Betancur2https://orcid.org/0000-0002-8145-0710Oriana Arias-Valderrama3https://orcid.org/0000-0001-9792-2359Jacobo Triviño-Arias4https://orcid.org/0009-0002-8295-3958Jessica Largo5https://orcid.org/0000-0002-2982-4498Viviana Lotero6https://orcid.org/0000-0003-3635-409XAlexis Franco7https://orcid.org/0000-0002-3173-6059Ximena Castro8https://orcid.org/0000-0002-8614-654XPamela Rodríguez9https://orcid.org/0000-0002-6217-2065Luz Angela Urcuqui10https://orcid.org/0000-0003-3542-4754Diego Medina11https://orcid.org/0000-0002-1465-7957Manuela Olaya12https://orcid.org/0000-0002-3239-8928Departamento de Medicina, Facultad de Salud, Universidad ICESI, Cali, ColombiaDepartamento de Medicina, Facultad de Salud, Universidad ICESI, Cali, ColombiaCentro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, ColombiaDepartamento de Medicina, Facultad de Salud, Universidad ICESI, Cali, Colombia; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, ColombiaCentro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, ColombiaCentro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, ColombiaDepartamento de Hemato-oncología Pediátrica, Fundación Valle del Lili, Cali, ColombiaDepartamento de Hemato-oncología Pediátrica, Fundación Valle del Lili, Cali, ColombiaDepartamento de Hemato-oncología Pediátrica, Fundación Valle del Lili, Cali, ColombiaDepartamento de Hemato-oncología Pediátrica, Fundación Valle del Lili, Cali, ColombiaDepartamento de Hemato-oncología Pediátrica, Fundación Valle del Lili, Cali, ColombiaDepartamento de Hemato-oncología Pediátrica, Fundación Valle del Lili, Cali, ColombiaDepartamento de Medicina, Facultad de Salud, Universidad ICESI, Cali, Colombia; Departamento de Alergología Pediátrica, Fundación Valle del Lili, Cali, ColombiaIntroduction. Immunodeficiencies are disturbances in the immune system that can affect cell function, quantity, or both. They can be either primary, associated with genetic defects, or secondary, linked to external factors such as hemato-oncological conditions. Secondary immunodeficiencies can lead to the initiation, reactivation, or acceleration of latent, residual, or active infections, which are the leading cause of mortality. Objective. To elucidate the occurrence and clinical characteristics of hypogammaglobulinemia in pediatric oncology patients in a high-complexity hospital in Colombia between January 2020 and December 2022. Materials and methods. We conducted an observational study with patients under 18 years old with a cancer diagnosis, serum immunoglobulins measurements at the time of the diagnosis, and later follow-up during treatment. Results. We included 133 patients with a median age of eight years. Based on local guidelines of immunoglobulin levels for age, all patients had normal values at the time of cancer diagnosis. In the follow-up, the most significant reduction among all ages was for IgA and was related to infections and death. Conclusions. Our findings highlight the importance of measuring immunoglobulin levels at the time of the cancer diagnosis, as hypogammaglobulinemia may be linked to a poorer prognosis. Early detection could potentially improve patient outcomes.https://revistabiomedica.org/index.php/biomedica/article/view/7584agammaglobulinemianeoplasmspediatricschild |
| spellingShingle | Ana Lucía Guzmán Isabella Villamil Sofía Martínez-Betancur Oriana Arias-Valderrama Jacobo Triviño-Arias Jessica Largo Viviana Lotero Alexis Franco Ximena Castro Pamela Rodríguez Luz Angela Urcuqui Diego Medina Manuela Olaya Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study Biomédica: revista del Instituto Nacional de Salud agammaglobulinemia neoplasms pediatrics child |
| title | Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study |
| title_full | Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study |
| title_fullStr | Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study |
| title_full_unstemmed | Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study |
| title_short | Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study |
| title_sort | understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children a retrospective cohort study |
| topic | agammaglobulinemia neoplasms pediatrics child |
| url | https://revistabiomedica.org/index.php/biomedica/article/view/7584 |
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