Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications
Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supp...
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| Format: | Article |
| Language: | English |
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2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/252647 |
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| author | Zahra Ajdari Maaruf Abd Ghani Mohd Khan Ayob Saadi Bayat Mazlin Mokhtar Sahar Abbasiliasi Anahita Khoramnia Heshu Sulaiman Rahman Parvaneh Mehrbod Daniel Ajdari Arbakariya B. Ariff |
| author_facet | Zahra Ajdari Maaruf Abd Ghani Mohd Khan Ayob Saadi Bayat Mazlin Mokhtar Sahar Abbasiliasi Anahita Khoramnia Heshu Sulaiman Rahman Parvaneh Mehrbod Daniel Ajdari Arbakariya B. Ariff |
| author_sort | Zahra Ajdari |
| collection | DOAJ |
| description | Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds. |
| format | Article |
| id | doaj-art-dc5510825154411198bbc35bbcc7fa14 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-dc5510825154411198bbc35bbcc7fa142025-02-03T01:28:02ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/252647252647Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food ApplicationsZahra Ajdari0Maaruf Abd Ghani1Mohd Khan Ayob2Saadi Bayat3Mazlin Mokhtar4Sahar Abbasiliasi5Anahita Khoramnia6Heshu Sulaiman Rahman7Parvaneh Mehrbod8Daniel Ajdari9Arbakariya B. Ariff10School of Chemical Sciences & Food Technology, Faculty of Science & Technology, MANIS Lab, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaSchool of Chemical Sciences & Food Technology, Faculty of Science & Technology, MANIS Lab, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaSchool of Chemical Sciences & Food Technology, Faculty of Science & Technology, MANIS Lab, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaInstitute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaDepartment of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaFaculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartmet of Microbiology and Pathology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaFaculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Marine Biotechnology, Iranian Fisheries Research Organization, No. 297, West Fatemi Avenue, P.O. Box 14155-6116, Tehran 1411816616, IranDepartment of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaHypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.http://dx.doi.org/10.1155/2014/252647 |
| spellingShingle | Zahra Ajdari Maaruf Abd Ghani Mohd Khan Ayob Saadi Bayat Mazlin Mokhtar Sahar Abbasiliasi Anahita Khoramnia Heshu Sulaiman Rahman Parvaneh Mehrbod Daniel Ajdari Arbakariya B. Ariff Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications The Scientific World Journal |
| title | Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications |
| title_full | Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications |
| title_fullStr | Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications |
| title_full_unstemmed | Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications |
| title_short | Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications |
| title_sort | hypocholesterolemic activity of monascus fermented product in the absence of monacolins with partial purification for functional food applications |
| url | http://dx.doi.org/10.1155/2014/252647 |
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