Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience
Apoptosis is critical for organ development, tissue homeostasis, the elimination of abnormal cells and the maintenance of immune homeostasis by variable regulatory mechanisms. The death of T lymphocytes following their activation involves a series of proteases (caspases), which comprise the central...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/527060 |
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| author | Jannis Kountouras Georgios Kouklakis Christos Zavos Dimitrios Chatzopoulos John Moschos Epaminodas Molyvas Nikolaos Zavos |
| author_facet | Jannis Kountouras Georgios Kouklakis Christos Zavos Dimitrios Chatzopoulos John Moschos Epaminodas Molyvas Nikolaos Zavos |
| author_sort | Jannis Kountouras |
| collection | DOAJ |
| description | Apoptosis is critical for organ development, tissue homeostasis, the elimination of abnormal cells and the maintenance of immune homeostasis by variable regulatory mechanisms. The death of T lymphocytes following their activation involves a series of proteases (caspases), which comprise the central executioners of apoptosis. Abnormal regulation of apoptosis results in disease. T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of the chronic inflammatory process in inflammatory bowel disease with potential tumourigenic effect. The use of antitumour necrosis factor-alpha, anti-interleukin-6R and anti-interleukin-12 antibodies suppresses colitis activity by induction of T-cell apoptosis, thereby having important implications for the design of effective therapeutic strategies in inflammatory bowel diseases. Contrary to international data, the incidence of cancer in Greek patients with inflammatory bowel disease appears to be low. A balance between cell proliferation (Ki-67 overexpression) and apoptosis (Bax protein overexpression) may partly explain the low incidence of cancer development in Greek inflammatory bowel disease patients. |
| format | Article |
| id | doaj-art-dc44214a68034c2987559f369fed995f |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-dc44214a68034c2987559f369fed995f2025-02-03T01:30:09ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117424925810.1155/2003/527060Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek ExperienceJannis Kountouras0Georgios Kouklakis1Christos Zavos2Dimitrios Chatzopoulos3John Moschos4Epaminodas Molyvas5Nikolaos Zavos6Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, GreeceGastroenterology Department, 424 General Military Hospital, Thessaloniki, GreeceDepartment of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, GreeceDepartment of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, GreeceGastroenterology Department, 424 General Military Hospital, Thessaloniki, GreeceGastroenterology Department, 424 General Military Hospital, Thessaloniki, GreeceDepartment of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, GreeceApoptosis is critical for organ development, tissue homeostasis, the elimination of abnormal cells and the maintenance of immune homeostasis by variable regulatory mechanisms. The death of T lymphocytes following their activation involves a series of proteases (caspases), which comprise the central executioners of apoptosis. Abnormal regulation of apoptosis results in disease. T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of the chronic inflammatory process in inflammatory bowel disease with potential tumourigenic effect. The use of antitumour necrosis factor-alpha, anti-interleukin-6R and anti-interleukin-12 antibodies suppresses colitis activity by induction of T-cell apoptosis, thereby having important implications for the design of effective therapeutic strategies in inflammatory bowel diseases. Contrary to international data, the incidence of cancer in Greek patients with inflammatory bowel disease appears to be low. A balance between cell proliferation (Ki-67 overexpression) and apoptosis (Bax protein overexpression) may partly explain the low incidence of cancer development in Greek inflammatory bowel disease patients.http://dx.doi.org/10.1155/2003/527060 |
| spellingShingle | Jannis Kountouras Georgios Kouklakis Christos Zavos Dimitrios Chatzopoulos John Moschos Epaminodas Molyvas Nikolaos Zavos Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience Canadian Journal of Gastroenterology |
| title | Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience |
| title_full | Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience |
| title_fullStr | Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience |
| title_full_unstemmed | Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience |
| title_short | Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience |
| title_sort | apoptosis inflammatory bowel disease and carcinogenesis overview of international and greek experience |
| url | http://dx.doi.org/10.1155/2003/527060 |
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