Neonatal Sepsis due to Coagulase-Negative Staphylococci
Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/586076 |
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| author | Elizabeth A. Marchant Guilaine K. Boyce Manish Sadarangani Pascal M. Lavoie |
| author_facet | Elizabeth A. Marchant Guilaine K. Boyce Manish Sadarangani Pascal M. Lavoie |
| author_sort | Elizabeth A. Marchant |
| collection | DOAJ |
| description | Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although advanced neonatal care enables us to save even the most preterm neonates, the very interventions sustaining those who are hospitalized concurrently expose them to serious infections due to common nosocomial pathogens, particularly coagulase-negative staphylococci bacteria (CoNS). Moreover, the health burden from infection in these infants remains unacceptably high despite continuing efforts. In this paper, we review the epidemiology, immunological risk factors, diagnosis, prevention, treatment, and outcomes of neonatal infection due to the predominant neonatal pathogen CoNS. |
| format | Article |
| id | doaj-art-dc42ed717c834a79929d8a60dfdea4aa |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-dc42ed717c834a79929d8a60dfdea4aa2025-02-03T01:04:52ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/586076586076Neonatal Sepsis due to Coagulase-Negative StaphylococciElizabeth A. Marchant0Guilaine K. Boyce1Manish Sadarangani2Pascal M. Lavoie3Child and Family Research Institute, 4th Floor, Translational Research Building, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, CanadaChild and Family Research Institute, 4th Floor, Translational Research Building, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, CanadaDepartment of Pediatrics, University of British Columbia, Vancouver, BC, V6T 1ZA, CanadaChild and Family Research Institute, 4th Floor, Translational Research Building, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, CanadaNeonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although advanced neonatal care enables us to save even the most preterm neonates, the very interventions sustaining those who are hospitalized concurrently expose them to serious infections due to common nosocomial pathogens, particularly coagulase-negative staphylococci bacteria (CoNS). Moreover, the health burden from infection in these infants remains unacceptably high despite continuing efforts. In this paper, we review the epidemiology, immunological risk factors, diagnosis, prevention, treatment, and outcomes of neonatal infection due to the predominant neonatal pathogen CoNS.http://dx.doi.org/10.1155/2013/586076 |
| spellingShingle | Elizabeth A. Marchant Guilaine K. Boyce Manish Sadarangani Pascal M. Lavoie Neonatal Sepsis due to Coagulase-Negative Staphylococci Clinical and Developmental Immunology |
| title | Neonatal Sepsis due to Coagulase-Negative Staphylococci |
| title_full | Neonatal Sepsis due to Coagulase-Negative Staphylococci |
| title_fullStr | Neonatal Sepsis due to Coagulase-Negative Staphylococci |
| title_full_unstemmed | Neonatal Sepsis due to Coagulase-Negative Staphylococci |
| title_short | Neonatal Sepsis due to Coagulase-Negative Staphylococci |
| title_sort | neonatal sepsis due to coagulase negative staphylococci |
| url | http://dx.doi.org/10.1155/2013/586076 |
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