Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma

Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma

Abstract Background Epithelial ovarian cancer (EOC) is a deadly and heterogenous disease comprising five major histotypes: clear cell carcinoma (CCC), endometrioid carcinoma (EC), low- and high-grade serous carcinoma (LGSC, HGSC), and mucinous carcinoma (MC). Despite this heterogeneity, EOC is often...

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Main Authors: Hugo Swenson, Ella Ittner, Lucas Werner, Elisabeth Werner Rönnerman, Claudia Mateoiu, Anikó Kovács, Pernilla Dahm-Kähler, Ghassan M. Saed, Szilárd Nemes, Per Karlsson, Toshima Z. Parris, Khalil Helou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Gene expression
DNA methylation
Bioinformatics
Machine learning
Online Access:https://doi.org/10.1186/s13048-025-01676-5
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