Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macropha...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6494795 |
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| _version_ | 1832551910894206976 |
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| author | Chang Xia Xiaoquan Rao Jixin Zhong |
| author_facet | Chang Xia Xiaoquan Rao Jixin Zhong |
| author_sort | Chang Xia |
| collection | DOAJ |
| description | Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future. |
| format | Article |
| id | doaj-art-dc39e852b5ca4d3481c08fdfc2bce769 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-dc39e852b5ca4d3481c08fdfc2bce7692025-02-03T06:00:14ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/64947956494795Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated InflammationChang Xia0Xiaoquan Rao1Jixin Zhong2College of Health Science & Nursing, Wuhan Polytechnic University, Wuhan, Hubei, ChinaCardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USACardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USAAlthough a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.http://dx.doi.org/10.1155/2017/6494795 |
| spellingShingle | Chang Xia Xiaoquan Rao Jixin Zhong Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation Journal of Diabetes Research |
| title | Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation |
| title_full | Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation |
| title_fullStr | Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation |
| title_full_unstemmed | Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation |
| title_short | Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation |
| title_sort | role of t lymphocytes in type 2 diabetes and diabetes associated inflammation |
| url | http://dx.doi.org/10.1155/2017/6494795 |
| work_keys_str_mv | AT changxia roleoftlymphocytesintype2diabetesanddiabetesassociatedinflammation AT xiaoquanrao roleoftlymphocytesintype2diabetesanddiabetesassociatedinflammation AT jixinzhong roleoftlymphocytesintype2diabetesanddiabetesassociatedinflammation |