Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis
Background. Left ventricular systolic dysfunction (LVSD) is common in sepsis. Speckle-tracking echocardiography (STE) is a useful emerging tool for evaluating the intrinsic left ventricular systolic function. High-sensitivity cardiac troponin T (hs-cTnT) is the most sensitive biomarker of myocardial...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/8897738 |
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| author | Pham Dang Hai Nguyen Thanh Binh Nguyen Hong Tot Ha Manh Hung Le Thi Viet Hoa Nguyen Viet Quang Hien Pham Nguyen Son |
| author_facet | Pham Dang Hai Nguyen Thanh Binh Nguyen Hong Tot Ha Manh Hung Le Thi Viet Hoa Nguyen Viet Quang Hien Pham Nguyen Son |
| author_sort | Pham Dang Hai |
| collection | DOAJ |
| description | Background. Left ventricular systolic dysfunction (LVSD) is common in sepsis. Speckle-tracking echocardiography (STE) is a useful emerging tool for evaluating the intrinsic left ventricular systolic function. High-sensitivity cardiac troponin T (hs-cTnT) is the most sensitive biomarker of myocardial injury. However, there are limited data regarding the association between hs-cTnT level and left ventricular systolic dysfunction based on STE in septic patients. We performed this prospective study to evaluate the diagnostic value of hs-cTnT level for subclinical left ventricular systolic dysfunction measured by STE in septic patients according to the sepsis-3 definition. Methods. Patients with sepsis based on sepsis-3 definition admitted to the intensive care unit were prospectively performed STE and hs-cTnT level within 24 hours after the onset of sepsis. Baseline clinical and echocardiographic variables were collected. Left ventricular systolic dysfunction was defined as a global longitudinal strain of ≥−15%. Results. During a 19-month period, 116 patients were enrolled in the study. The elevated hs-cTnT level was seen in 86.2% of septic patients, and 43.1% of patients had LVSD on STE. The median hs-cTnT level and the proportion of elevated hs-cTnT level (>14 ng/L) were significantly higher in patients with LVSD than in patients without LVSD. The area under the ROC curves of hs-cTnT to detect LVSD was 0.73 (P < 0.001). In the multivariate analysis, hs-cTnT (HR, 1.002; 95% CI, 1.000 to 1.004; P = 0.025) and septic shock (HR, 7.6; 95% CI, 2.25 to 25.76; P = 0.001) were independent predictors of LVSD. Conclusion. Our study indicated that the serum hs-cTnT level might be a useful biomarker for detecting LVSD in septic patients. |
| format | Article |
| id | doaj-art-dc38d26a48ab4fad8660aa4f0b53c088 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-dc38d26a48ab4fad8660aa4f0b53c0882025-02-03T05:57:52ZengWileyCardiology Research and Practice2090-80162090-05972021-01-01202110.1155/2021/88977388897738Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with SepsisPham Dang Hai0Nguyen Thanh Binh1Nguyen Hong Tot2Ha Manh Hung3Le Thi Viet Hoa4Nguyen Viet Quang Hien5Pham Nguyen Son6Intensive Care Unit, 108 Military Central Hospital, Hanoi, VietnamIntensive Care Unit, 108 Military Central Hospital, Hanoi, VietnamIntensive Care Unit, 108 Military Central Hospital, Hanoi, VietnamIntensive Care Unit, 108 Military Central Hospital, Hanoi, VietnamIntensive Care Unit, Tam Anh Hospital, Hanoi, VietnamDepartment of Anesthesiology and Critical Care Medicine, Hue Central Hospital, Hue, VietnamDepartment of Cardiology, 108 Military Central Hospital, Hanoi, VietnamBackground. Left ventricular systolic dysfunction (LVSD) is common in sepsis. Speckle-tracking echocardiography (STE) is a useful emerging tool for evaluating the intrinsic left ventricular systolic function. High-sensitivity cardiac troponin T (hs-cTnT) is the most sensitive biomarker of myocardial injury. However, there are limited data regarding the association between hs-cTnT level and left ventricular systolic dysfunction based on STE in septic patients. We performed this prospective study to evaluate the diagnostic value of hs-cTnT level for subclinical left ventricular systolic dysfunction measured by STE in septic patients according to the sepsis-3 definition. Methods. Patients with sepsis based on sepsis-3 definition admitted to the intensive care unit were prospectively performed STE and hs-cTnT level within 24 hours after the onset of sepsis. Baseline clinical and echocardiographic variables were collected. Left ventricular systolic dysfunction was defined as a global longitudinal strain of ≥−15%. Results. During a 19-month period, 116 patients were enrolled in the study. The elevated hs-cTnT level was seen in 86.2% of septic patients, and 43.1% of patients had LVSD on STE. The median hs-cTnT level and the proportion of elevated hs-cTnT level (>14 ng/L) were significantly higher in patients with LVSD than in patients without LVSD. The area under the ROC curves of hs-cTnT to detect LVSD was 0.73 (P < 0.001). In the multivariate analysis, hs-cTnT (HR, 1.002; 95% CI, 1.000 to 1.004; P = 0.025) and septic shock (HR, 7.6; 95% CI, 2.25 to 25.76; P = 0.001) were independent predictors of LVSD. Conclusion. Our study indicated that the serum hs-cTnT level might be a useful biomarker for detecting LVSD in septic patients.http://dx.doi.org/10.1155/2021/8897738 |
| spellingShingle | Pham Dang Hai Nguyen Thanh Binh Nguyen Hong Tot Ha Manh Hung Le Thi Viet Hoa Nguyen Viet Quang Hien Pham Nguyen Son Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis Cardiology Research and Practice |
| title | Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis |
| title_full | Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis |
| title_fullStr | Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis |
| title_full_unstemmed | Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis |
| title_short | Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis |
| title_sort | diagnostic value of high sensitivity troponin t for subclinical left ventricular systolic dysfunction in patients with sepsis |
| url | http://dx.doi.org/10.1155/2021/8897738 |
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