Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze
Background. A reliable asthma diagnosis is challenging in preschool wheezing children. As inhaled corticosteroids (ICS) are more effective in asthmatics than in children with transient wheeze, an ICS response might be helpful in early asthma diagnosis. Methods. 175 children (aged two–four years) wit...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/162571 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556507144650752 |
|---|---|
| author | E. M. M. Klaassen K. D. G. van de Kant Q. Jöbsis S. T. P. Høvig C. P. van Schayck G. T. Rijkers E. Dompeling |
| author_facet | E. M. M. Klaassen K. D. G. van de Kant Q. Jöbsis S. T. P. Høvig C. P. van Schayck G. T. Rijkers E. Dompeling |
| author_sort | E. M. M. Klaassen |
| collection | DOAJ |
| description | Background. A reliable asthma diagnosis is challenging in preschool wheezing children. As inhaled corticosteroids (ICS) are more effective in asthmatics than in children with transient wheeze, an ICS response might be helpful in early asthma diagnosis. Methods. 175 children (aged two–four years) with recurrent wheeze received 200 μg Beclomethasone extra-fine daily for eight weeks. Changes in Exhaled Breath Condensate (EBC) biomarkers (pH, interleukin (IL)-1α, IL-2, IL-4, IL-5, IL-10, IFN-γ, sICAM, and CCL-11), Fractional exhaled Nitric Oxide (FeNO), airway resistance, and symptoms were assessed. At six years of age a child was diagnosed as transient wheezer or asthmatic. Adjusted logistic regression analysis was performed with multiple testing correction. Results. 106 transient wheezers and 64 asthmatics were analysed at six years of age. Neither changes in EBC biomarkers, nor FeNO, airway resistance, or symptoms during ICS trial at preschool age were related to asthma diagnosis at six years of age. However, asthmatics had more airway symptoms before the start of the ICS trial than transient wheezers (P<0.01). Discussion. Although symptom score in preschool wheezing children at baseline was associated with asthma at six years of age, EBC biomarkers, airway resistance, or symptom response to ICS at preschool age could not predict asthma diagnosis at six years of age. |
| format | Article |
| id | doaj-art-dc25de06b61647229f71180441defef6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dc25de06b61647229f71180441defef62025-02-03T05:45:15ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/162571162571Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent WheezeE. M. M. Klaassen0K. D. G. van de Kant1Q. Jöbsis2S. T. P. Høvig3C. P. van Schayck4G. T. Rijkers5E. Dompeling6Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of General Practice, CAPHRI, MUMC, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Medical Microbiology and Immunology, Sint Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The NetherlandsDepartment of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsBackground. A reliable asthma diagnosis is challenging in preschool wheezing children. As inhaled corticosteroids (ICS) are more effective in asthmatics than in children with transient wheeze, an ICS response might be helpful in early asthma diagnosis. Methods. 175 children (aged two–four years) with recurrent wheeze received 200 μg Beclomethasone extra-fine daily for eight weeks. Changes in Exhaled Breath Condensate (EBC) biomarkers (pH, interleukin (IL)-1α, IL-2, IL-4, IL-5, IL-10, IFN-γ, sICAM, and CCL-11), Fractional exhaled Nitric Oxide (FeNO), airway resistance, and symptoms were assessed. At six years of age a child was diagnosed as transient wheezer or asthmatic. Adjusted logistic regression analysis was performed with multiple testing correction. Results. 106 transient wheezers and 64 asthmatics were analysed at six years of age. Neither changes in EBC biomarkers, nor FeNO, airway resistance, or symptoms during ICS trial at preschool age were related to asthma diagnosis at six years of age. However, asthmatics had more airway symptoms before the start of the ICS trial than transient wheezers (P<0.01). Discussion. Although symptom score in preschool wheezing children at baseline was associated with asthma at six years of age, EBC biomarkers, airway resistance, or symptom response to ICS at preschool age could not predict asthma diagnosis at six years of age.http://dx.doi.org/10.1155/2012/162571 |
| spellingShingle | E. M. M. Klaassen K. D. G. van de Kant Q. Jöbsis S. T. P. Høvig C. P. van Schayck G. T. Rijkers E. Dompeling Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze Mediators of Inflammation |
| title | Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze |
| title_full | Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze |
| title_fullStr | Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze |
| title_full_unstemmed | Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze |
| title_short | Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze |
| title_sort | symptoms but not a biomarker response to inhaled corticosteroids predict asthma in preschool children with recurrent wheeze |
| url | http://dx.doi.org/10.1155/2012/162571 |
| work_keys_str_mv | AT emmklaassen symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze AT kdgvandekant symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze AT qjobsis symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze AT stphøvig symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze AT cpvanschayck symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze AT gtrijkers symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze AT edompeling symptomsbutnotabiomarkerresponsetoinhaledcorticosteroidspredictasthmainpreschoolchildrenwithrecurrentwheeze |