Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis
Leydig cell tumor is a rare sex cord tumor that accounts for 1–3% of all testicular neoplasms. Seminomas are more common and occur in 30–40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2018/8747131 |
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| _version_ | 1832567341147226112 |
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| author | Ifeyinwa E. Obiorah Alexandra Kyrillos Metin Ozdemirli |
| author_facet | Ifeyinwa E. Obiorah Alexandra Kyrillos Metin Ozdemirli |
| author_sort | Ifeyinwa E. Obiorah |
| collection | DOAJ |
| description | Leydig cell tumor is a rare sex cord tumor that accounts for 1–3% of all testicular neoplasms. Seminomas are more common and occur in 30–40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry. To our knowledge, this is the first diagnosis of the two disease entities in a unilateral testis using immunohistochemistry. Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management. |
| format | Article |
| id | doaj-art-dc1690daa3744926a90b5a249a9894f7 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-dc1690daa3744926a90b5a249a9894f72025-02-03T01:01:46ZengWileyCase Reports in Urology2090-696X2090-69782018-01-01201810.1155/2018/87471318747131Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral TestisIfeyinwa E. Obiorah0Alexandra Kyrillos1Metin Ozdemirli2Department of Pathology, MedStar Georgetown University Hospital, Washington, DC, USADepartment of Pathology, MedStar Georgetown University Hospital, Washington, DC, USADepartment of Pathology, MedStar Georgetown University Hospital, Washington, DC, USALeydig cell tumor is a rare sex cord tumor that accounts for 1–3% of all testicular neoplasms. Seminomas are more common and occur in 30–40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry. To our knowledge, this is the first diagnosis of the two disease entities in a unilateral testis using immunohistochemistry. Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management.http://dx.doi.org/10.1155/2018/8747131 |
| spellingShingle | Ifeyinwa E. Obiorah Alexandra Kyrillos Metin Ozdemirli Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis Case Reports in Urology |
| title | Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis |
| title_full | Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis |
| title_fullStr | Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis |
| title_full_unstemmed | Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis |
| title_short | Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis |
| title_sort | synchronous leydig cell tumor and seminoma in the ipsilateral testis |
| url | http://dx.doi.org/10.1155/2018/8747131 |
| work_keys_str_mv | AT ifeyinwaeobiorah synchronousleydigcelltumorandseminomaintheipsilateraltestis AT alexandrakyrillos synchronousleydigcelltumorandseminomaintheipsilateraltestis AT metinozdemirli synchronousleydigcelltumorandseminomaintheipsilateraltestis |