Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.

Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.

<h4>Background</h4>Ulcerative colitis (UC) and Crohn's disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with considerable morbidity. The hedgehog (HH) signalling pathway, which includes the transcription factor glioma-associ...

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Main Authors: Charlie W Lees, William J Zacharias, Mark Tremelling, Colin L Noble, Elaine R Nimmo, Albert Tenesa, Jennine Cornelius, Leif Torkvist, John Kao, Susan Farrington, Hazel E Drummond, Gwo-Tzer Ho, Ian D R Arnott, Henry D Appelman, Lauri Diehl, Harry Campbell, Malcolm G Dunlop, Miles Parkes, Sarah E M Howie, Deborah L Gumucio, Jack Satsangi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0050239&type=printable
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