Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM
Background. Intrapancreatic fat deposition (IPFD) usually occurs in individuals with type 2 diabetes mellitus (T2DM), but its physiopathological influence remains controversial. The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in i...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/6991633 |
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| author | Jianliang Wang Qingyun Cai Xiaojuan Wu Jiaxuan Wang Xiaona Chang Xiaoyu Ding Jia Liu Guang Wang |
| author_facet | Jianliang Wang Qingyun Cai Xiaojuan Wu Jiaxuan Wang Xiaona Chang Xiaoyu Ding Jia Liu Guang Wang |
| author_sort | Jianliang Wang |
| collection | DOAJ |
| description | Background. Intrapancreatic fat deposition (IPFD) usually occurs in individuals with type 2 diabetes mellitus (T2DM), but its physiopathological influence remains controversial. The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in individuals with newly diagnosed T2DM. Methods. A total of 100 individuals were included, consisting of 80 patients with newly diagnosed T2DM and 20 age- and sex-matched healthy controls. Then, we assessed IPFD using magnetic resonance imaging (MRI) and various parameters of glucose and lipid metabolism. Results. Individuals with newly diagnosed T2DM had a significantly higher IPFD (median: 12.34%; IQR, 9.19–16.60%) compared with healthy controls (median: 6.35%; IQR, 5.12–8.96%) p<0.001. In individuals with newly diagnosed T2DM, IPFD was significantly associated with FINS and HOMA-IR in unadjusted model (β = 0.239, p=0.022; β = 0.578, p=0.007, respectively) and adjusted model for age and sex (β = 0.241, p=0.022; β = 0.535, p=0.014, respectively), but these associations vanished after adjustment for age, sex, and BMI. The OR of lower HDL-C for the prevalence of high IPFD was 4.22 (95% CI, 1.41 to 12.69; p=0.010) after adjustment for age, sex, BMI, and HbA1c. Conclusions. Lower HDL-C was an independent predictor for a high degree of IPFD. |
| format | Article |
| id | doaj-art-dc0269e7350443b5b79a6227b23d6294 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-dc0269e7350443b5b79a6227b23d62942025-02-03T06:08:47ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/6991633Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DMJianliang Wang0Qingyun Cai1Xiaojuan Wu2Jiaxuan Wang3Xiaona Chang4Xiaoyu Ding5Jia Liu6Guang Wang7General Surgery DepartmentDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyBackground. Intrapancreatic fat deposition (IPFD) usually occurs in individuals with type 2 diabetes mellitus (T2DM), but its physiopathological influence remains controversial. The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in individuals with newly diagnosed T2DM. Methods. A total of 100 individuals were included, consisting of 80 patients with newly diagnosed T2DM and 20 age- and sex-matched healthy controls. Then, we assessed IPFD using magnetic resonance imaging (MRI) and various parameters of glucose and lipid metabolism. Results. Individuals with newly diagnosed T2DM had a significantly higher IPFD (median: 12.34%; IQR, 9.19–16.60%) compared with healthy controls (median: 6.35%; IQR, 5.12–8.96%) p<0.001. In individuals with newly diagnosed T2DM, IPFD was significantly associated with FINS and HOMA-IR in unadjusted model (β = 0.239, p=0.022; β = 0.578, p=0.007, respectively) and adjusted model for age and sex (β = 0.241, p=0.022; β = 0.535, p=0.014, respectively), but these associations vanished after adjustment for age, sex, and BMI. The OR of lower HDL-C for the prevalence of high IPFD was 4.22 (95% CI, 1.41 to 12.69; p=0.010) after adjustment for age, sex, BMI, and HbA1c. Conclusions. Lower HDL-C was an independent predictor for a high degree of IPFD.http://dx.doi.org/10.1155/2023/6991633 |
| spellingShingle | Jianliang Wang Qingyun Cai Xiaojuan Wu Jiaxuan Wang Xiaona Chang Xiaoyu Ding Jia Liu Guang Wang Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM International Journal of Endocrinology |
| title | Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM |
| title_full | Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM |
| title_fullStr | Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM |
| title_full_unstemmed | Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM |
| title_short | Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM |
| title_sort | association between intrapancreatic fat deposition and lower high density lipoprotein cholesterol in individuals with newly diagnosed t2dm |
| url | http://dx.doi.org/10.1155/2023/6991633 |
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