Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Eukaryotic cells have evolved to use complex pathways for DNA damage signaling and repair to maintain genomic integrity. RNF168 is a novel E3 ligase that functions downstream of ATM,γ-H2A.X, MDC1, and RNF8. It has been shown to ubiquitylate histone H2A and to facilitate the recruitment of other DNA...

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Main Authors: Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Stephanie Panier, Dimphy Zeegers, Li Li, Grant S Stewart, Otto Sanchez, M Prakash Hande, Daniel Durocher, Anne Hakem, Razqallah Hakem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001381&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001381&type=printable

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