The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data
PurposeThis study aims to investigate the relationship between the body roundness index (BRI) and overall mortality rates in individuals with osteoporosis (OP), utilizing information sourced from the NHANES database, in order to assess BRI’s capability as an indicator for predicting mortality risk.M...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1538766/full |
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| author | Ziyao Ding Ziyao Ding Ziyao Ding Wenbo Li Wenbo Li Wenbo Li Haixu Qi Haixu Qi Haixu Qi Tianci Fang Qirui Zhu Qirui Zhu Qirui Zhu Xinzhe Qu Xinzhe Qu Changchang Chen Jun Sun Jun Sun Yong Pang |
| author_facet | Ziyao Ding Ziyao Ding Ziyao Ding Wenbo Li Wenbo Li Wenbo Li Haixu Qi Haixu Qi Haixu Qi Tianci Fang Qirui Zhu Qirui Zhu Qirui Zhu Xinzhe Qu Xinzhe Qu Changchang Chen Jun Sun Jun Sun Yong Pang |
| author_sort | Ziyao Ding |
| collection | DOAJ |
| description | PurposeThis study aims to investigate the relationship between the body roundness index (BRI) and overall mortality rates in individuals with osteoporosis (OP), utilizing information sourced from the NHANES database, in order to assess BRI’s capability as an indicator for predicting mortality risk.MethodsData from NHANES (2005 to 2010, 2013–2014, and 2017–2018) were analyzed, including 1,596 osteoporotic individuals aged 50 and above. BRI was calculated based on waist circumference (WC) and height, categorizing participants into high (>4.07) and low (≤4.07) BRI groups. To analyze the relationship between BRI and mortality while accounting for important covariates, we employed weighted Cox proportional hazards models, conducted Kaplan–Meier survival analyses, and utilized restricted cubic splines (RCS).ResultsHigher BRI was significantly associated with better long-term survival, showing an “L”-shaped nonlinear inverse relationship with mortality, with a threshold at BRI = 5. In subgroup analyses, this association remained relatively stable.ConclusionThe “L”-shaped association between BRI and mortality indicates that BRI may serve as a useful indicator for evaluating mortality risk in patients with OP, thereby informing clinical interventions and public health approaches. |
| format | Article |
| id | doaj-art-dbf955557819447c8bf847518bac7e18 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-dbf955557819447c8bf847518bac7e182025-01-20T05:23:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15387661538766The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES dataZiyao Ding0Ziyao Ding1Ziyao Ding2Wenbo Li3Wenbo Li4Wenbo Li5Haixu Qi6Haixu Qi7Haixu Qi8Tianci Fang9Qirui Zhu10Qirui Zhu11Qirui Zhu12Xinzhe Qu13Xinzhe Qu14Changchang Chen15Jun Sun16Jun Sun17Yong Pang18First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaPurposeThis study aims to investigate the relationship between the body roundness index (BRI) and overall mortality rates in individuals with osteoporosis (OP), utilizing information sourced from the NHANES database, in order to assess BRI’s capability as an indicator for predicting mortality risk.MethodsData from NHANES (2005 to 2010, 2013–2014, and 2017–2018) were analyzed, including 1,596 osteoporotic individuals aged 50 and above. BRI was calculated based on waist circumference (WC) and height, categorizing participants into high (>4.07) and low (≤4.07) BRI groups. To analyze the relationship between BRI and mortality while accounting for important covariates, we employed weighted Cox proportional hazards models, conducted Kaplan–Meier survival analyses, and utilized restricted cubic splines (RCS).ResultsHigher BRI was significantly associated with better long-term survival, showing an “L”-shaped nonlinear inverse relationship with mortality, with a threshold at BRI = 5. In subgroup analyses, this association remained relatively stable.ConclusionThe “L”-shaped association between BRI and mortality indicates that BRI may serve as a useful indicator for evaluating mortality risk in patients with OP, thereby informing clinical interventions and public health approaches.https://www.frontiersin.org/articles/10.3389/fnut.2025.1538766/fullbody roundness index (BRI)bone mineral density (BMD)osteoporosisNHANESall-cause mortality |
| spellingShingle | Ziyao Ding Ziyao Ding Ziyao Ding Wenbo Li Wenbo Li Wenbo Li Haixu Qi Haixu Qi Haixu Qi Tianci Fang Qirui Zhu Qirui Zhu Qirui Zhu Xinzhe Qu Xinzhe Qu Changchang Chen Jun Sun Jun Sun Yong Pang The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data Frontiers in Nutrition body roundness index (BRI) bone mineral density (BMD) osteoporosis NHANES all-cause mortality |
| title | The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data |
| title_full | The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data |
| title_fullStr | The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data |
| title_full_unstemmed | The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data |
| title_short | The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data |
| title_sort | l shaped association between body roundness index and all cause mortality in osteoporotic patients a cohort study based on nhanes data |
| topic | body roundness index (BRI) bone mineral density (BMD) osteoporosis NHANES all-cause mortality |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1538766/full |
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