Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab
Patients receiving complement inhibitor, eculizumab, are at high risk for infections with encapsulated organisms such as Neisseria due to impaired opsonophagocytic activity. Impaired complement immunity may increase the risk for dissemination of asymptomatic Neisseria gonorrhoeae. Disseminated Gonoc...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/9713413 |
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| _version_ | 1832556639160369152 |
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| author | Nakul Katyal Latika Nirola Naureen Narula Raghav Govindarajan |
| author_facet | Nakul Katyal Latika Nirola Naureen Narula Raghav Govindarajan |
| author_sort | Nakul Katyal |
| collection | DOAJ |
| description | Patients receiving complement inhibitor, eculizumab, are at high risk for infections with encapsulated organisms such as Neisseria due to impaired opsonophagocytic activity. Impaired complement immunity may increase the risk for dissemination of asymptomatic Neisseria gonorrhoeae. Disseminated Gonococcal Infection (DGI) is a rare but potentially life-threatening complication associated with eculizumab. Physicians should obtain adequate sexual histories from the patients and educate them on safe sexual practices. Here, we describe a case of DGI in a 32-year-old African American female patient with acetylcholine receptor antibody-positive (AChR+) generalized myasthenia gravis (gMG), receiving eculizumab. |
| format | Article |
| id | doaj-art-dbebe57cbac14aa4997618f958ed2720 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-dbebe57cbac14aa4997618f958ed27202025-02-03T05:44:44ZengWileyCase Reports in Neurological Medicine2090-66682090-66762021-01-01202110.1155/2021/97134139713413Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with EculizumabNakul Katyal0Latika Nirola1Naureen Narula2Raghav Govindarajan3Department of Neurology, University of Missouri, Columbia, MO, USAGuru Gobind Singh Medical College and Hospital, Faridkot, Punjab, IndiaDepartment of Pulmonology and Critical Care Medicine, Staten Island University Hospital, New York, NY, USADepartment of Neurology, University of Missouri, Columbia, MO, USAPatients receiving complement inhibitor, eculizumab, are at high risk for infections with encapsulated organisms such as Neisseria due to impaired opsonophagocytic activity. Impaired complement immunity may increase the risk for dissemination of asymptomatic Neisseria gonorrhoeae. Disseminated Gonococcal Infection (DGI) is a rare but potentially life-threatening complication associated with eculizumab. Physicians should obtain adequate sexual histories from the patients and educate them on safe sexual practices. Here, we describe a case of DGI in a 32-year-old African American female patient with acetylcholine receptor antibody-positive (AChR+) generalized myasthenia gravis (gMG), receiving eculizumab.http://dx.doi.org/10.1155/2021/9713413 |
| spellingShingle | Nakul Katyal Latika Nirola Naureen Narula Raghav Govindarajan Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab Case Reports in Neurological Medicine |
| title | Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab |
| title_full | Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab |
| title_fullStr | Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab |
| title_full_unstemmed | Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab |
| title_short | Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab |
| title_sort | diffuse gonococcal infection dgi in a patient with treatment refractory acetylcholine receptor antibody positive achr generalized myasthenia gravis gmg treated with eculizumab |
| url | http://dx.doi.org/10.1155/2021/9713413 |
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