Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair

Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair

Abstract The biological process of fracture repair involves inflammation, vascularization, endochondral ossification, and cartilage production. Long non-coding RNAs (lncRNAs) are essential for the growth and maintenance of the skeleton. In this study, the role of the long non-coding RNA H19 in endoc...

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Bibliographic Details
Main Authors: Qiuyue Sun, Chen Zhang, Bowen Chen, Junyi Liao, Aowen Bao, Chen Zhao, Hong Chen, Dawei He, Wei Huang, Guangming Dai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Fracture repair
Vascularization
Endochondral ossification
Long non-coding RNA H19
miR-21a-5p
smad7
Online Access:https://doi.org/10.1038/s41598-025-11300-7
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