Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection
Hemophagocytic lymphohistiocytosis (HLH), while uncommon, may be a devastating complication of lymphoma and/or human immunodeficiency virus (HIV) infection. While several of the diagnostic criteria for HLH are relatively nonspecific, particularly in the setting of a systemic inflammatory response, m...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/687260 |
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| author | Marc Uemura Richard Huynh Allen Kuo Fernando Antelo Robert Deiss James Yeh |
| author_facet | Marc Uemura Richard Huynh Allen Kuo Fernando Antelo Robert Deiss James Yeh |
| author_sort | Marc Uemura |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH), while uncommon, may be a devastating complication of lymphoma and/or human immunodeficiency virus (HIV) infection. While several of the diagnostic criteria for HLH are relatively nonspecific, particularly in the setting of a systemic inflammatory response, more diagnostic specificity may be achieved with marked elevations in serum ferritin (e.g., >100,000 ng/mL). Increased suspicion of HLH, particularly in the setting of persistent, unexplained fevers, pancytopenia, and transaminitis, should prompt consideration of HLH. Earlier diagnosis and initiation of therapy have the potential to alter the natural history and poor prognosis of this disorder. We present a patient with HIV infection who developed relapsed T-cell lymphoma complicated by hemophagocytic lymphohistiocytosis. |
| format | Article |
| id | doaj-art-dbd5c6cdfeb64dd7b986d36bff67f94e |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-dbd5c6cdfeb64dd7b986d36bff67f94e2025-08-20T03:24:20ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/687260687260Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV InfectionMarc Uemura0Richard Huynh1Allen Kuo2Fernando Antelo3Robert Deiss4James Yeh5Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USADepartment of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USADepartment of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USADepartment of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90502, USADivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA 90502, USADepartment of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USAHemophagocytic lymphohistiocytosis (HLH), while uncommon, may be a devastating complication of lymphoma and/or human immunodeficiency virus (HIV) infection. While several of the diagnostic criteria for HLH are relatively nonspecific, particularly in the setting of a systemic inflammatory response, more diagnostic specificity may be achieved with marked elevations in serum ferritin (e.g., >100,000 ng/mL). Increased suspicion of HLH, particularly in the setting of persistent, unexplained fevers, pancytopenia, and transaminitis, should prompt consideration of HLH. Earlier diagnosis and initiation of therapy have the potential to alter the natural history and poor prognosis of this disorder. We present a patient with HIV infection who developed relapsed T-cell lymphoma complicated by hemophagocytic lymphohistiocytosis.http://dx.doi.org/10.1155/2013/687260 |
| spellingShingle | Marc Uemura Richard Huynh Allen Kuo Fernando Antelo Robert Deiss James Yeh Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection Case Reports in Hematology |
| title | Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection |
| title_full | Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection |
| title_fullStr | Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection |
| title_short | Hemophagocytic Lymphohistiocytosis Complicating T-Cell Lymphoma in a Patient with HIV Infection |
| title_sort | hemophagocytic lymphohistiocytosis complicating t cell lymphoma in a patient with hiv infection |
| url | http://dx.doi.org/10.1155/2013/687260 |
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