The role and mechanism of TSC in kidney diseases: a literature review

The role and mechanism of TSC in kidney diseases: a literature review

Abstract Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by multisystem involvement, primarily caused by loss-of-function mutations in the TSC1 or TSC2 genes. TSC is a key integrator of metabolic signaling and cellular stress and has become an impo...

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Main Authors: Qiulin Luo, Xinguo Zheng, Ye Xu, Yuxi Fan, Hedong Zhang, Tengfang Li, Xiangqi Zhang, Longkai Peng, Xin Jiang, Helong Dai
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Nephrology
Subjects:
Tuberous sclerosis complex
Kidney diseases
mTOR inhibitors
Immunotherapeutic
Online Access:https://doi.org/10.1186/s12882-025-04260-7
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