Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy
Hepatic encephalopathy (HE) is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes, particularly in cases of severe liver disease or cirrhosis. Previous studies have reported spatially distrib...
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KeAi Communications Co. Ltd.
2025-05-01
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| Series: | Magnetic Resonance Letters |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772516224000639 |
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| author | Guanchen Sha Yuefan Liu Yutong Cao Qi Zhang Yining Zhang Yuanyuan Chen Qiuyun Fan Yue Cheng |
| author_facet | Guanchen Sha Yuefan Liu Yutong Cao Qi Zhang Yining Zhang Yuanyuan Chen Qiuyun Fan Yue Cheng |
| author_sort | Guanchen Sha |
| collection | DOAJ |
| description | Hepatic encephalopathy (HE) is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes, particularly in cases of severe liver disease or cirrhosis. Previous studies have reported spatially distributed structural and functional abnormalities related to HE, but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear. In this study, we performed surface-based cortical thickness comparisons and functional connectivity (FC) analyses between three cross-sectional groups: healthy controls (HC, N = 51), patients with minimal hepatic encephalopathy (MHE, N = 50), patients with overt hepatic encephalopathy (OHE, N = 51). In addition to the distributed cortical thinning that is extensively thought to be associated with cognitive decline in HE, we found significant cortical thickening in the left parahippocampal gyrus cortex in the OHE group (p < 0.001, p = 0.009) as compared to the HC and MHE group respectively, which is further corroborated by the significant correlation between the cortical thickness and digit symbol test (DST) scores. Furthermore, the decreased FC between the right postcentral gyrus and several sensory regions (bilateral somatosensory and visual cortices) was found to be significant in MHE patients as compared to the HC group. Our results revealed cross-sectional structural and functional variations concerning disease progression across different subsystems (e.g., visual, motor and sensory), providing evidence that can potentially explain the mechanisms underlying the sensorimotor and cognitive deficits related to HE. |
| format | Article |
| id | doaj-art-dbccf0e91bd048f6bb3057c6ebfd3eec |
| institution | Kabale University |
| issn | 2772-5162 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co. Ltd. |
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| series | Magnetic Resonance Letters |
| spelling | doaj-art-dbccf0e91bd048f6bb3057c6ebfd3eec2025-08-20T03:26:20ZengKeAi Communications Co. Ltd.Magnetic Resonance Letters2772-51622025-05-015220015610.1016/j.mrl.2024.200156Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathyGuanchen Sha0Yuefan Liu1Yutong Cao2Qi Zhang3Yining Zhang4Yuanyuan Chen5Qiuyun Fan6Yue Cheng7Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China; Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin, 300072, ChinaDepartment of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China; Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin, 300072, ChinaTianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin, 300072, China; Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, ChinaDepartment of Medical Imaging, Tianjin First Central Hospital, Tianjin, 300192, ChinaDepartment of Medical Imaging, Tianjin First Central Hospital, Tianjin, 300192, ChinaTianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin, 300072, China; Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China; Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, 300392, ChinaDepartment of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China; Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin, 300072, China; Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China; Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, 300392, China; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin, 300072, China; Corresponding author. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.Department of Medical Imaging, Tianjin First Central Hospital, Tianjin, 300192, China; Corresponding author.Hepatic encephalopathy (HE) is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes, particularly in cases of severe liver disease or cirrhosis. Previous studies have reported spatially distributed structural and functional abnormalities related to HE, but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear. In this study, we performed surface-based cortical thickness comparisons and functional connectivity (FC) analyses between three cross-sectional groups: healthy controls (HC, N = 51), patients with minimal hepatic encephalopathy (MHE, N = 50), patients with overt hepatic encephalopathy (OHE, N = 51). In addition to the distributed cortical thinning that is extensively thought to be associated with cognitive decline in HE, we found significant cortical thickening in the left parahippocampal gyrus cortex in the OHE group (p < 0.001, p = 0.009) as compared to the HC and MHE group respectively, which is further corroborated by the significant correlation between the cortical thickness and digit symbol test (DST) scores. Furthermore, the decreased FC between the right postcentral gyrus and several sensory regions (bilateral somatosensory and visual cortices) was found to be significant in MHE patients as compared to the HC group. Our results revealed cross-sectional structural and functional variations concerning disease progression across different subsystems (e.g., visual, motor and sensory), providing evidence that can potentially explain the mechanisms underlying the sensorimotor and cognitive deficits related to HE.http://www.sciencedirect.com/science/article/pii/S2772516224000639Hepatic encephalopathySurface-based morphometry (SBM)Cortical thicknessSensorimotor |
| spellingShingle | Guanchen Sha Yuefan Liu Yutong Cao Qi Zhang Yining Zhang Yuanyuan Chen Qiuyun Fan Yue Cheng Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy Magnetic Resonance Letters Hepatic encephalopathy Surface-based morphometry (SBM) Cortical thickness Sensorimotor |
| title | Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy |
| title_full | Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy |
| title_fullStr | Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy |
| title_full_unstemmed | Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy |
| title_short | Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy |
| title_sort | structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy |
| topic | Hepatic encephalopathy Surface-based morphometry (SBM) Cortical thickness Sensorimotor |
| url | http://www.sciencedirect.com/science/article/pii/S2772516224000639 |
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