Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery

Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery

The growing demand for viral vectors as nanoscale therapeutic agents in gene therapy necessitates efficient and scalable purification methods. This study examined the role of nanoscale biomaterials in optimizing viral vector clarification through a model system mimicking real AAV2 crude harvest mate...

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Bibliographic Details
Main Authors: Mara Leach, Kearstin Edmonds, Emily Ingram, Rebecca Dutch, Ranil Wickramasinghe, Malgorzata Chwatko, Dibakar Bhattacharyya
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Nanomaterials
Subjects:
AAV2
silica nanoparticles
membrane filtration
fouling models
downstream bioprocessing
gene therapy
Online Access:https://www.mdpi.com/2079-4991/15/4/310
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