Neutral Protamine Hagedorn (NPH) insulin attenuates memory impairments in diabetic rats

Neutral Protamine Hagedorn (NPH) insulin attenuates memory impairments in diabetic rats

Abstract Cognitive decline is a significant complication of type 1 diabetes (T1D) that substantially affects patients' quality of life. Although previous studies suggest that Neutral Protamine Hagedorn (NPH) insulin may mitigate certain effects of streptozotocin-induced type 1 diabetes (T1DSTZ)...

Full description

Saved in:

Bibliographic Details
Main Authors:	Marcelo T. Andrade, Camila B. Gomes, Débora O. Fernandes, Bruno P. Melo, Michele M. Moraes, Ana F. S. Almeida, Laura F. J. Alvarado, Grace S. Pereira, Juliana B. Guimarães, Elsa Heyman, Romain Meeusen, Thiago T. Mendes, Danusa D. Soares
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Diabetology & Metabolic Syndrome
Subjects:	Cognitive impairment Diabetes complications Insulin therapy Memory deficits Neuroprotection Streptozotocin-induced diabetes
Online Access:	https://doi.org/10.1186/s13098-025-01820-7
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Impact of switching from neutral protamine hagedorn insulin (NPH) to glargine insulin on glycemic control and clinical outcomes in pediatric patients with type 1 diabetes
by: Hiba Abdelmunim Suliman Elsheikh, et al.
Published: (2025-06-01)

Obtaining a mouse model of streptozotocininduced type 1 diabetes mellitus
by: G. N. Skaletskaya, et al.
Published: (2024-07-01)

Effect of cubebin against streptozotocin-induced diabetic nephropathy rats via inhibition TNF-α/NF-κB/TGF-β: in vivo and in silico study
by: Rahamat Unissa Syed, et al.
Published: (2025-02-01)

Electrical activity in rat retina in a streptozotocin-induced diabetes model
by: Ekaterina M. Klochihina, et al.
Published: (2018-11-01)

Manifestation of pathognomonic signs in modeling diabetes mellitus with streptozotocin in BALB/c mice
by: A. V. Sorokina, et al.
Published: (2023-01-01)

Morphology of bronchial epithelium in rodent streptozotocin-induced diabetes mellitus
by: Oksana Anatolyevna Pivovarova, et al.
Published: (2013-12-01)

Immunomodulatory Effect of Rivaroxaban Nanoparticles Alone and in Combination with Sitagliptin on Diabetic Rat Model
by: Mohamed M. Elbadr, et al.
Published: (2025-03-01)

Switching from Neutral Protamine Hagedorn Insulin to Insulin Glargine 300 U/mL Improves Glycaemic Control and Reduces Hypoglycaemia Risk: Results of a Multicentre, Prospective, Observational Study
by: B. Wolnik, et al.
Published: (2020-01-01)

The initial level of heart rate variability determines the dynamics of the neuropathy of the autonomic nervous system and temperature sensitivity in rats with streptozotocin diabetes
by: Maria P. Morozova, et al.
Published: (2019-08-01)

Streptozotocin-induced diabetes duration is important to determine changes in the number and basophily of myenteric neurons
by: LUZMARINA HERNANDES, et al.
Published: (2000-12-01)

Streptozotocin model of stable diabetes mellitus
by: G. N. Skaletskaya, et al.
Published: (2019-01-01)

EVALUATION OF THE EFFECT OF FLAVONOID EXTRACT OF Ginkgo biloba LEAVES AND GLIMEPHAN ON OXIDATIVE STRESS AND RETINA DEGENERATION IN DIABETIC MALE RABBITS INDUCED BY STREPTOZOTOCIN
by: Wasan A. Jawad, et al.
Published: (2020-06-01)

Hypoglycemic Activity of Endophytic Extract of Senna Alata in STZ-Induced Diabetic Mice Model
by: Ogechukwu Lucy Nwankwo, et al.
Published: (2021-07-01)

The evaluation of the effects of natural zeolite (Clinoptilolite) in diabetic rats on bone healing in dental extracting socket
by: İstemihan Çelikbaş, et al.
Published: (2023-01-01)

Pinitol Improves Diabetic Foot Ulcers in Streptozotocin-Induced Diabetes Rats Through Upregulation of Nrf2/HO-1 Signaling
by: Jinsick Kim, et al.
Published: (2024-12-01)

Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats
by: Indu Raghunath, et al.
Published: (2025-07-01)

Effect of Ethanolic Extract of Azadirachta Indica (Neem) Gum on Fasting Lipid Profile on Female Streptozotocin Induced Diabetes Rats
by: Aiki, G.*1, Dallatu, M. K.1, Abubakar, I. A.2,Suleiman, N.3, Wali, U. 1, Ngaski, A. A.1, Bunza, J. M.1 and AbubakarU. 4
Published: (2024-07-01)

Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice
by: Weibin Wu, et al.
Published: (2025-07-01)

Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice
by: Steven R. Talbot, et al.
Published: (2024-07-01)

Establishment of rat model of diabetic nephropathy induced by left nephrectomy combined with intraperitoneal injection of streptozotocin
by: GAO Jun-li, et al.
Published: (2018-01-01)

Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats
by: Emmanuel Saviour Saheed, et al.
Published: (2025-04-01)

State of peroxidation in the brain and liver in experimental diabetes and its correction possibility with niacin-oxyethylendiphosphonatogermanate
by: V. Y. Kresiun, et al.
Published: (2023-10-01)

Potential role of ghrelin in neuroprotection and cognitive function: implications for diabetic cognitive impairment
by: Yuhan Zhang, et al.
Published: (2025-02-01)

Exploring the antidiabetic potential of Bridelia tomentosa blume against streptozotocin (STZ)-induced diabetic Sprague-Dawley rats
by: Kakoli Rani Mondal, et al.
Published: (2025-08-01)

Antidiabetic effects of Peganum harmala seed extract on streptozotocin-induced diabetes in rats
by: Mozafar Khazaei, et al.
Published: (2025-06-01)

POTENTIAL OF ROSELLA FLOWER EXTRACT KEFIR (HIBISCUS SABDARIFFA L.) IN REDUCING PANCREATIC β- CELL DAMAGE IN DIABETES MELLITUS MODEL RATS (RATTUS NORVEGICUS)
by: Viani Anggi, et al.
Published: (2025-07-01)

Morphometric changes in the heart of rats with alloxan and streptozotocin diabetes
by: Saule Zhautikova, et al.
Published: (2024-12-01)

Effects of Sargassum Glaucescens Algae on Blood Glucose Level in Diabetic Rats With a High-Fat Diet and Streptozotocin
by: Esmaeel Ghani, et al.
Published: (2024-09-01)

Ficus deltoidea standardized methanolic extract improves kidney structure and function against streptozotocin-induced diabetic nephropathy in rats
by: Nurdiana Samsulrizal, et al.
Published: (2025-02-01)

In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways
by: Khalid Saad Alharbi, et al.
Published: (2025-01-01)

Lipid metabolism in streptozotocin induced experimental diabetes and it’s correction with niacin-oxyethylidendiphosphonatogermanate
by: N. V. Kresyun, et al.
Published: (2017-08-01)

Comparison between basal insulin glargine and NPH insulin in patients with diabetes type 1 on conventional intensive insulin therapy
by: Pešić Milica, et al.
Published: (2007-01-01)

Specific efficiency of microemulsion matrix transdermal delivery system of insulin (experimental model of diabetes mellitus typeI)
by: E. G. Kuznetsova, et al.
Published: (2017-09-01)

Risk of endothelial dysfunction in streptozotocin-induced diabetic Sprague-Dawley rats: Nitric oxide in focus
by: M.L. Jidda J.M. Bunza M.K. Dallatu L.S. Bilbis A.J. Alhassan Muhammad Yelwa Gwarzo A.A. Ngaski A.F. Chiroma S.L. Kakako Maryam Kasimu B.M. Yale M. Kasimu S. Haruna K.A. Ogunwale A. K. Bello Ibrahim Kalle Kwaifa
Published: (2023-09-01)

Assessing the efficacy of methanol extracts of Ocimum sanctum linn. and Ocimum basilicum linn. in diabetic neuropathy
by: Khan Shabeena, et al.
Published: (2025-01-01)

Protective effects of Morus alba Linn leaf extract on streptozotocin-induced diabetic nephropathy in mice model
by: Ngoc Kim Nguyen, et al.
Published: (2025-08-01)

Model of the formation of streptozotocin-induced diabetes in Wiesenau pigs with assessment of its effectiveness and stability
by: P. S. Ermakova, et al.
Published: (2025-05-01)

HYPOGLYCEMIC EFFECT OF SITAGLIPTIN AND AMINOGUANIDINE COMBINATION IN EXPERIMENTAL DIABETES MELLITUS
by: D. V. Kurkin, et al.
Published: (2023-02-01)

Enhancing diabetic rat peripheral nerve conduction velocity parameters through the potent effects of MitoTEMPO
by: Murat Cenk Celen, et al.
Published: (2024-12-01)

Effect of Advillin Knockout on Diabetic Neuropathy Induced by Multiple Low Doses of Streptozotocin
by: Yu-Chia Chuang, et al.
Published: (2025-01-01)